Drug Delivery Research Group, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India.
Indian J Dermatol Venereol Leprol. 2010 Nov-Dec;76(6):612-21. doi: 10.4103/0378-6323.72451.
Psoriasis is a chronic inflammatory skin disorder that may drastically impair the quality of life of a patient. Among the various modes of treatments for psoriasis, topical therapy is most commonly used in majority of patients. The topical formulations based on conventional excipients could serve the purpose only to a limited extent. With the advent of newer biocompatible and biodegradable materials like phospholipids, and cutting-edge drug delivery technologies like liposomes, solid lipid nanoparticles (SLNs), microemulsions, and nanoemulsions, the possibility to improve the efficacy and safety of the topical products has increased manifold. Improved understanding of the dermal delivery aspects and that of designing and developing diverse carrier systems have brought in further novelty in this approach. Substantial efforts and the consequent publications, patents and product development studies on the subject are the matter of interest and review of this article. However, majority of the work is related to the preclinical studies and demands further clinical assessment in psoriasis patients.
银屑病是一种慢性炎症性皮肤病，可能会极大地降低患者的生活质量。在银屑病的各种治疗方法中，大多数患者最常使用局部治疗。基于传统赋形剂的局部制剂只能在有限的程度上达到治疗效果。随着磷脂等新型生物相容性和可生物降解材料以及脂质体、固体脂质纳米粒 (SLN)、微乳液和纳米乳液等先进药物传递技术的出现，提高局部产品疗效和安全性的可能性大大增加。对皮肤传递方面的深入理解，以及对各种载体系统的设计和开发，为这种方法带来了进一步的创新。在这一领域，大量的工作和相关的出版物、专利和产品开发研究是本文的关注和综述的内容。然而，大多数工作都与临床前研究有关，需要在银屑病患者中进一步进行临床评估。
