Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Dermatol Venereol Leprol. 2010 Nov-Dec;76(6):622-33. doi: 10.4103/0378-6323.72454.
Psoriasis is a common debilitating disease significantly affecting the quality of life of the patients. Majority of the psoriasis patients have mild disease which can be managed by topical therapies. Around 30% of the psoriasis patients require systemic therapy during the course of their disease. There is a vast array of drugs for the treatment. Methotrexate, cyclosporine and retinoids are the most commonly used conventional systemic drugs. Newer studies provide insight into their more effective and safer use and as combination therapy with biologics. In recent times, many new drugs with novel mechanisms of action other than biologics have been tried in psoriasis. In this article, we have reviewed the current developments and new found role of the conventional drugs as well as the newer nonbiologic systemic drugs in the treatment of psoriasis.
银屑病是一种常见的使人衰弱的疾病，极大地影响了患者的生活质量。大多数银屑病患者的病情较轻，可以通过局部治疗来控制。大约 30%的银屑病患者在疾病过程中需要全身治疗。有各种各样的药物可供治疗。甲氨蝶呤、环孢素和维 A 酸类药物是最常用的传统全身药物。新的研究为它们的更有效和更安全的使用提供了深入了解，并与生物制剂联合使用。最近，在银屑病的治疗中，尝试了许多具有除生物制剂以外的新型作用机制的新药。在本文中，我们综述了传统药物以及新型非生物制剂全身药物在银屑病治疗中的最新进展和新发现的作用。
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