Ciotta L, Stracquadanio M, Pagano I, Carbonaro A, Palumbo M, Gulino F
Sezione di Ginecologia, Dipartimento di Scienze Microbiologiche e Scienze Ginecologiche, Ospedale Santo BambinoUniversità degli Studi di Catania, Catania, Italia.
Minerva Ginecol. 2010 Dec;62(6):525-31.
Polycystic ovary syndrome is the most common cause of chronic anovulation infertility in women in fertile period. The supplementation of inositol, due to its ability to increase insulin sensitivity, improves the oocytes' quality and increase the number of oocytes collected after ovarian stimulation in patients undergoing IVF (In Vitro Fertilization). The aim of our study is to determine the effects of myo-inositol on oocyte's quality on a sample of women with polycystic ovary syndrome.
The patients were divided into two groups: patients of Group A intook 2 g of myo-inositol + 400 μg of folic acid 2 times a day, continuously for 3 months, while Group B only 400 μg of folic acid.
At the end of treatment, the number of follicles of diameter >15 mm, visible at ultrasound during stimulation, and the number of oocytes recovered at the time of pick-ups were found to be significantly greater in the group treated with myo-inositol, so as the average number of embryos transferred and embryo Grade G1. Significantly reduced was the average number of immature oocytes (vesicles germ and degenerated oocytes) too.
多囊卵巢综合征是育龄期女性慢性无排卵性不孕最常见的原因。由于肌醇能够提高胰岛素敏感性，因此补充肌醇可改善卵母细胞质量，并增加接受体外受精（IVF）的患者在卵巢刺激后采集的卵母细胞数量。我们研究的目的是确定肌醇对多囊卵巢综合征女性样本中卵母细胞质量的影响。
将患者分为两组：A组患者每天服用2克肌醇 + 400微克叶酸，持续3个月，每天2次，而B组仅服用400微克叶酸。
治疗结束时，发现接受肌醇治疗的组中，刺激期间超声可见的直径>15毫米的卵泡数量、取卵时回收的卵母细胞数量、移植的胚胎平均数量以及G1级胚胎数量均显著增加。未成熟卵母细胞（囊胚和退化卵母细胞）的平均数量也显著减少。
