Microbiological and Gynecological Science Department, Gynecology Section Santo Bambino Hospital (Catania), University of Catania, Italy.
Eur Rev Med Pharmacol Sci. 2011 May;15(5):509-14.
Polycystic ovary syndrome is the most common cause of chronic anovulation infertility in women in fertile period, and it's characterized by an increased production of androgens and estrogens. The administration of myo-inositol, a B complex vitamin, was associated with a decreased of serum testosterone and simultaneously, due to its ability to increase insulin sensitivity, women who received myo-inositol showed a great improvement of the ovulary function. Besides, the supplementation of inositol improves the oocytes' quality and increase the number of oocytes collected after ovarian stimulation in patients undergoing IVF (in vitro fertilization).
The aim of this study is to determine the effects of myo-inositol on oocyte's quality on a sample of women with polycystic ovary syndrome.
The patients were divided into two groups: patients of Group A in-took 2 g of myo-inositol + 200 microg of folic acid (Inofolic, LO.LI. Pharma, Rome, Italy) while Group B only 200 microg of folic acid, both groups took the treatment twice a day, continuously for 3 months.
At the end of treatment, the number of follicles of diameter > 15 mm, visible at ultrasound during stimulation, and the number of oocytes recovered at the time of pick-ups were found to be significantly greater in the group treated with myo-inositol, so as the aver-age number of embryos transferred and embryo Score S1. Significantly reduced was the average number of immature oocytes (vesicles germ and degenerated oocytes) too.
These data suggest that myoinositol may be useful in the treatment of PCOS patients undergoing ovulation induction, both for its insulin-sensitizing activity, and its role in oocyte maturation.
多囊卵巢综合征是育龄期女性慢性无排卵性不孕的最常见原因，其特征是雄激素和雌激素的产生增加。肌醇，一种 B 族维生素，的给药与血清睾酮的降低有关，同时，由于其增加胰岛素敏感性的能力，接受肌醇治疗的女性表现出排卵功能的极大改善。此外，补充肌醇可改善卵子质量，并增加接受体外受精（IVF）的患者在卵巢刺激后采集的卵子数量。
本研究旨在确定肌醇对多囊卵巢综合征患者卵子质量的影响。
患者分为两组：A 组患者服用 2 克肌醇+200 微克叶酸（Inofolic，LO.LI. Pharma，罗马，意大利），而 B 组仅服用 200 微克叶酸，两组均每天服用两次，连续服用 3 个月。
治疗结束时，超声可见刺激过程中直径>15 毫米的卵泡数量和抽吸时回收的卵子数量在肌醇治疗组明显增加，因此转移的胚胎平均数量和胚胎评分 S1 也增加。不成熟卵子（原始卵泡和退化卵子）的平均数量也明显减少。
这些数据表明，肌醇可能对接受排卵诱导的多囊卵巢综合征患者有用，这既是因为其胰岛素增敏作用，也是因为其在卵子成熟中的作用。
