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Histone methyltransferase G9a contributes to H3K27 methylation in vivo.

作者信息

Wu Hui, Chen Xiuzhen, Xiong Jun, Li Yingfeng, Li Hong, Ding Xiaojun, Liu Sheng, Chen She, Gao Shaorong, Zhu Bing

出版信息

Cell Res. 2011 Feb;21(2):365-7. doi: 10.1038/cr.2010.157. Epub 2010 Nov 16.

DOI:10.1038/cr.2010.157
PMID:21079650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3193445/
Abstract
摘要

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Histone methyltransferase G9a contributes to H3K27 methylation in vivo.组蛋白甲基转移酶G9a在体内有助于H3K27甲基化。
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2
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3
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本文引用的文献

1
Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly.组蛋白 H3-H4 四聚体在 DNA 复制依赖性染色质组装过程中的分配。
Science. 2010 Apr 2;328(5974):94-8. doi: 10.1126/science.1178994.
2
A systematic evaluation of the compatibility of histones containing methyl-lysine analogues with biochemical reactions.对含甲基赖氨酸类似物的组蛋白与生化反应兼容性的系统评估。
Cell Res. 2009 Oct;19(10):1217-20. doi: 10.1038/cr.2009.110. Epub 2009 Sep 22.
3
Chemical derivatization of histones for facilitated analysis by mass spectrometry.用于通过质谱法进行便捷分析的组蛋白化学衍生化。
Nat Protoc. 2007;2(4):933-8. doi: 10.1038/nprot.2007.106.
4
The site-specific installation of methyl-lysine analogs into recombinant histones.将甲基赖氨酸类似物位点特异性安装到重组组蛋白中。
Cell. 2007 Mar 9;128(5):1003-12. doi: 10.1016/j.cell.2006.12.041.
5
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.Suz12对小鼠发育以及EZH2组蛋白甲基转移酶活性至关重要。
EMBO J. 2004 Oct 13;23(20):4061-71. doi: 10.1038/sj.emboj.7600402. Epub 2004 Sep 23.
6
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.EED-EZH2复合物的组蛋白甲基转移酶活性和沉默功能均需要SUZ12。
Mol Cell. 2004 Jul 2;15(1):57-67. doi: 10.1016/j.molcel.2004.06.020.
7
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.G9a组蛋白甲基转移酶在常染色质组蛋白H3赖氨酸9甲基化过程中起主导作用，并且对早期胚胎发育至关重要。
Genes Dev. 2002 Jul 15;16(14):1779-91. doi: 10.1101/gad.989402.
8
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics.细胞培养中氨基酸稳定同位素标记法（SILAC），作为一种用于表达蛋白质组学的简单且准确的方法。
Mol Cell Proteomics. 2002 May;1(5):376-86. doi: 10.1074/mcp.m200025-mcp200.
9
Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3.含SET结构域蛋白G9a是一种新型的优先作用于赖氨酸的哺乳动物组蛋白甲基转移酶，对组蛋白H3的赖氨酸9和27具有高活性和特异性选择性。
J Biol Chem. 2001 Jul 6;276(27):25309-17. doi: 10.1074/jbc.M101914200. Epub 2001 Apr 20.