Richards C, Thomas P
Pharmacy Department, University Hospital of Wales, Heath Park, Cardiff.
J Clin Pharm Ther. 1990 Feb;15(1):53-8. doi: 10.1111/j.1365-2710.1990.tb00356.x.
We studied the retention of endotoxin released in a clinically relevant form by senescent bacteria during filtration of amino acid-based total parenteral nutrition (TPN) solutions by the PALL Intravenous Set Saver Filter (ELD96). The ELD96 was shown to be capable of providing an effluent free of detectable endotoxin (less than 0.125 endotoxin unit-equivalents/ml) when challenged with 10(6) total cells of Pseudomonas aeruginosa during simulated clinical TPN infusion. Parallel control experiments showed that endotoxin was released from the test organism and penetrated through conventional intravenous (i.v.) solution filters.
我们研究了在基于氨基酸的全胃肠外营养（TPN）溶液通过颇尔静脉留置针保护过滤器（ELD96）过滤过程中，衰老细菌以临床相关形式释放的内毒素的截留情况。当在模拟临床TPN输注过程中用10⁶个铜绿假单胞菌总细胞进行挑战时，ELD96能够提供不含可检测到的内毒素（小于0.125内毒素单位当量/毫升）的流出液。平行对照实验表明，内毒素从受试生物体中释放出来并穿透传统的静脉内（i.v.）溶液过滤器。
