两种“96小时”在线静脉滤器内毒素截留能力的比较。

A comparison of the endotoxin-retentive abilities of two '96-h' in-line intravenous filters.

作者信息

Richards C, Grassby P F

机构信息

Sterile Product Unit, University Hospital of Wales, Cardiff, U.K.

出版信息

J Clin Pharm Ther. 1994 Jun;19(3):199-202. doi: 10.1111/j.1365-2710.1994.tb00673.x.

DOI:10.1111/j.1365-2710.1994.tb00673.x

PMID:7962224

Abstract

The ability of two in-line intravenous filters, the Pall Intravenous Set Saver Filter ELD96 and the Codan I.V. S SET-P, to retain endotoxin released by Pseudomonas aeruginosa during filtration of amino-acid-based parenteral nutrition (PN) solutions was investigated. When challenged with 10(8) cells of P. aeruginosa during simulated clinical PN infusion, the Pall ELD96 was shown to be capable of providing an effluent free of detectable endotoxin (< 0.3125 EUE/ml). In contrast, the Codan I.V. S SET-P allowed significant amounts of endotoxin to pass through.

摘要

研究了两种串联静脉滤器——颇尔静脉输液套装保护滤器ELD96和科丹静脉输液套装S SET-P，在过滤氨基酸型肠外营养（PN）溶液过程中截留铜绿假单胞菌释放的内毒素的能力。在模拟临床PN输注过程中用10⁸个铜绿假单胞菌细胞进行挑战时，结果显示颇尔ELD96能够提供无检测到内毒素（<0.3125 EU/ml）的流出液。相比之下，科丹静脉输液套装S SET-P允许大量内毒素通过。