Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA.
Chem Commun (Camb). 2011 Jan 7;47(1):532-4. doi: 10.1039/c0cc02923h. Epub 2010 Nov 16.
In this work, sub-50 nm pegylated mesoporous silica nanoparticles prepared with hydrothermal treatment are shown to have long-term stability in various media at both room and physiological temperature. Compared to bare mesoporous silica nanoparticles, the highly pegylated mesoporous silica nanoparticles show significantly improved biocompatibility and decreased macrophage uptake, making these nanoparticles viable for in vivo stealth drug delivery applications.
在这项工作中，通过水热法制备的亚 50nm 聚乙二醇化介孔硅纳米粒子在室温及生理温度的各种介质中都表现出长期的稳定性。与未修饰的介孔硅纳米粒子相比，高度聚乙二醇化的介孔硅纳米粒子表现出显著提高的生物相容性和降低的巨噬细胞摄取，这使得这些纳米粒子可用于体内隐形药物递送应用。
