Institute of Reproduction and Stem Cells Engineering, Central South University, Changsha, 410078, China.
J Assist Reprod Genet. 2011 Feb;28(2):151-6. doi: 10.1007/s10815-010-9497-1. Epub 2010 Nov 17.
To assess the long Y chromosome genetic effect on human pregnancy outcomes.
We studied all records of pregnancies by human sperm donors after artificial insemination or in vitro fertilization at the Reproductive and Genetic Hospital of Citic-Xiangya. Fetal losses were compared from two groups of sperm donors: the observation group (with long Y chromosome) and the control group (without long Y chromosome).
2885 pregnancies were achieved with donor sperm by artificial insemination and 1746 by in vitro fertilization. The rates of fetal loss, congenital malformation and donor fecundity in the observation group after both assisted reproductive technique were the same as for the control group.
A long Y chromosome may therefore be considered as a normal variant.
评估长 Y 染色体对人类妊娠结局的长期遗传影响。
我们研究了中信湘雅生殖与遗传专科医院通过人工授精或体外受精进行的所有人类精子供体妊娠记录。比较了两组精子供体的胎儿丢失率：观察组（具有长 Y 染色体）和对照组（无长 Y 染色体）。
2885 例采用供体精子行人工授精妊娠，1746 例采用体外受精妊娠。观察组在两种辅助生殖技术后，胎儿丢失率、先天性畸形率和供体生育力与对照组相同。
因此，长 Y 染色体可被视为一种正常变异。
