Yoon Dong Hyun, Nozaki Yoshito, Tanaka Daiki, Sekiguchi Tetsushi, Shoji Shuichi
Research Organization for Nano & Life Innovation, Waseda University, 513, Tsurumaki-cho, Waseda, Shinjuku-ku, Tokyo 162-0041, Japan.
Faculty of Science and Engineering, Waseda University, 3-4-1, Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
Micromachines (Basel). 2019 Sep 15;10(9):613. doi: 10.3390/mi10090613.
This paper presents a method for utilizing three-dimensional microfluidic channels fully to realize multiple functions in a single device. The final device structure was achieved by combining three independent modules that consisted of horizontal and vertical channels. The device allowed for the one-step generation of water-in-oil-in-water droplets without the need for partial treatment of the polydimethylsiloxane channel surface using separate modules for generating water-in-oil droplets on the horizontal plane and oil-in-water droplets on the vertical plane. The second vertically structured module provided an efficient flow for the generation of highly wettable liquid droplets, and tuning of the first horizontally structured module enabled different modes of inner-core encapsulation within the oil shell. The successful integration of the vertical and horizontal channels for core-shell droplet generation and the chemical synthesis of a metal complex within the droplets were evaluated. The proposed approach of integrating independent modules will expand and enhance the functions of microfluidic platforms.
本文提出了一种充分利用三维微流体通道以在单个设备中实现多种功能的方法。最终的设备结构是通过组合由水平和垂直通道组成的三个独立模块实现的。该设备允许一步生成水包油包水液滴，而无需使用单独模块对聚二甲基硅氧烷通道表面进行部分处理，这些单独模块用于在水平面上生成油包水液滴以及在垂直面上生成水包油液滴。第二个垂直结构模块为生成高度可湿化的液滴提供了高效流动，并且对第一个水平结构模块的调节实现了油壳内不同模式的心核封装。评估了用于核壳液滴生成以及液滴内金属配合物化学合成的垂直和水平通道成功集成情况。所提出的集成独立模块的方法将扩展并增强微流体平台的功能。
