Drivas G T, Shih A, Coutavas E, Rush M G, D'Eustachio P
Department of Biochemistry, New York University School of Medicine, New York 10016.
Mol Cell Biol. 1990 Apr;10(4):1793-8. doi: 10.1128/mcb.10.4.1793-1798.1990.
A mixed-oligonucleotide probe was used to identify four ras-like coding sequences in a human teratocarcinoma cDNA library. Two of these sequences resembled the rho genes, one was closely related to H-, K-, and N-ras, and one shared only the four sequence domains that define the ras gene superfamily. Homologs of the four genes were found in genomic DNA from a variety of mammals and from chicken. The genes were transcriptionally active in a range of human cell types.
使用混合寡核苷酸探针在人畸胎瘤cDNA文库中鉴定出四个类ras编码序列。其中两个序列类似于rho基因，一个与H-、K-和N-ras密切相关，另一个仅共享定义ras基因超家族的四个序列结构域。在多种哺乳动物和鸡的基因组DNA中发现了这四个基因的同源物。这些基因在一系列人类细胞类型中具有转录活性。
