Khare Sonal, Luc Nancy, Dorfleutner Andrea, Stehlik Christian
Division of Rheumatology, Department of Medicine and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Crit Rev Immunol. 2010;30(5):463-87. doi: 10.1615/critrevimmunol.v30.i5.50.
The innate immune system relies on the recognition of pathogens by pattern recognition receptors as a first line of defense and to initiate the adaptive immune response. Substantial progress has been made in defining the role of Nod (nucleotide-binding oligimerization domain)-like receptors and AIM2 (absent in melanoma 2) as pattern recognition receptors that activate inflammasomes in macrophages. Inflammasomes are protein platforms essential for the activation of inflammatory caspases and subsequent maturation of their pro-inflammatory cytokine substrates and induction of pyroptosis. This paper summarizes recent developments regarding the function of Nod-like receptors in immunity and disease.
先天免疫系统依靠模式识别受体识别病原体作为第一道防线，并启动适应性免疫反应。在确定Nod（核苷酸结合寡聚化结构域）样受体和AIM2（黑色素瘤2中缺失）作为激活巨噬细胞中炎性小体的模式识别受体的作用方面已经取得了重大进展。炎性小体是蛋白质平台，对于激活炎性半胱天冬酶、随后使其促炎细胞因子底物成熟以及诱导细胞焦亡至关重要。本文总结了关于Nod样受体在免疫和疾病中的功能的最新进展。
