中国南方多囊卵巢综合征青少年的代谢异常。
Metabolic abnormalities in adolescents with polycystic ovary syndrome in south China.
机构信息
Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
出版信息
Reprod Biol Endocrinol. 2010 Nov 17;8:142. doi: 10.1186/1477-7827-8-142.
BACKGROUND
Adults with polycystic ovary syndrome (PCOS) can have multiple metabolic abnormalities. However, studies in the adolescent population are still limited and these results seem to vary widely. This study was to investigate the metabolic abnormalities in adolescents with PCOS in South China and the potential risk factors contributed to these health risks.
METHODS
Anthropometric measurements and biochemical parameters were evaluated in 128 adolescents with PCOS and their age- and BMI-matched controls.
RESULTS
The prevalence of pre-diabetes, insulin resistance, hyperinsulinemia, dyslipidemia and metabolic syndrome in adolescents with PCOS was 11.7%, 46.9%, 29.7%, 22.7% and 4.7%, respectively. 16.3%, 74.4%, 67.4%, 39.5% and 14% of the PCOS subjects with BMI > 85th had pre-diabetes, insulin resistance, hyperinsulinemia, dyslipidemia and metabolic syndrome, whereas 9.4%, 32.9%, 10.6%, 14.1% and 0% of the PCOS subjects with BMI < 85th had such disturbances.
CONCLUSIONS
Adolescents with PCOS in South China had more metabolic abnormalities than their age- and BMI-matched non-PCOS counterparts. Obesity could worsen insulin resistance, hyperinsulinemia and metabolic syndrome in PCOS adolescents.
背景
患有多囊卵巢综合征（PCOS）的成年人可能存在多种代谢异常。然而，青少年人群中的研究仍然有限，而且这些结果似乎差异很大。本研究旨在调查中国南方青少年多囊卵巢综合征患者的代谢异常情况，以及导致这些健康风险的潜在危险因素。
方法
评估了 128 名多囊卵巢综合征青少年及其年龄和 BMI 匹配的对照组的人体测量学测量值和生化参数。
结果
多囊卵巢综合征青少年中糖尿病前期、胰岛素抵抗、高胰岛素血症、血脂异常和代谢综合征的患病率分别为 11.7%、46.9%、29.7%、22.7%和 4.7%。BMI > 85th 的多囊卵巢综合征患者中，16.3%、74.4%、67.4%、39.5%和 14%患有糖尿病前期、胰岛素抵抗、高胰岛素血症、血脂异常和代谢综合征，而 BMI < 85th 的多囊卵巢综合征患者中，分别有 9.4%、32.9%、10.6%、14.1%和 0%存在这些紊乱。
结论
中国南方的多囊卵巢综合征青少年比年龄和 BMI 匹配的非多囊卵巢综合征青少年有更多的代谢异常。肥胖可能会使多囊卵巢综合征青少年的胰岛素抵抗、高胰岛素血症和代谢综合征恶化。
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