The Jean Hailes Foundation for Women's Health Research Unit, Monash Institute of Health Services Research, Monash University, Clayton, Victoria, Australia.
Hum Reprod Update. 2010 Jul-Aug;16(4):347-63. doi: 10.1093/humupd/dmq001. Epub 2010 Feb 16.
BACKGROUND Polycystic ovary syndrome (PCOS) is a common condition in reproductive-aged women associated with impaired glucose tolerance (IGT), type 2 diabetes mellitus (DM2) and the metabolic syndrome. METHODS A literature search was conducted (MEDLINE, CINAHL, EMBASE, clinical trial registries and hand-searching) identifying studies reporting prevalence or incidence of IGT, DM2 or metabolic syndrome in women with and without PCOS. Data were presented as odds ratio (OR) [95% confidence interval (CI)] with fixed- and random-effects meta-analysis by Mantel-Haenszel methods. Quality testing was based on Newcastle-Ottawa Scaling and The Cochrane Collaboration's risk of bias assessment tool. Literature searching, data abstraction and quality appraisal were performed by two investigators. RESULTS A total of 2192 studies were reviewed and 35 were selected for final analysis. Women with PCOS had increased prevalence of IGT (OR 2.48, 95% CI 1.63, 3.77; BMI-matched studies OR 2.54, 95% CI 1.44, 4.47), DM2 (OR 4.43, 95% CI 4.06, 4.82; BMI-matched studies OR 4.00, 95% CI 1.97, 8.10) and metabolic syndrome (OR 2.88, 95% CI 2.40, 3.45; BMI-matched studies OR 2.20, 95% CI 1.36, 3.56). One study assessed IGT/DM2 incidence and reported no significant differences in DM2 incidence (OR 2.07, 95% CI 0.68, 6.30). One study assessed conversion from normal glucose tolerance to IGT/DM2 (OR 2.4, 95% CI 0.7, 8.0). No studies reported metabolic syndrome incidence. CONCLUSIONS Women with PCOS had an elevated prevalence of IGT, DM2 and metabolic syndrome in both BMI and non-BMI-matched studies. Few studies have determined IGT/DM2 or metabolic syndrome incidence in women with and without PCOS and further research is required.
多囊卵巢综合征（PCOS）是一种常见于育龄妇女的疾病，与葡萄糖耐量受损（IGT）、2 型糖尿病（DM2）和代谢综合征有关。
进行了文献检索（MEDLINE、CINAHL、EMBASE、临床试验注册处和手工检索），以确定报告患有和不患有 PCOS 的妇女中 IGT、DM2 或代谢综合征患病率或发病率的研究。数据以比值比（OR）[95%置信区间（CI）]表示，采用 Mantel-Haenszel 方法进行固定效应和随机效应荟萃分析。质量测试基于纽卡斯尔-渥太华量表和 Cochrane 协作组的偏倚风险评估工具。文献检索、数据提取和质量评估由两名研究人员进行。
共审查了 2192 项研究，最终有 35 项研究被纳入分析。患有 PCOS 的女性 IGT 患病率增加（OR 2.48，95%CI 1.63，3.77；BMI 匹配研究 OR 2.54，95%CI 1.44，4.47）、DM2（OR 4.43，95%CI 4.06，4.82；BMI 匹配研究 OR 4.00，95%CI 1.97，8.10）和代谢综合征（OR 2.88，95%CI 2.40，3.45；BMI 匹配研究 OR 2.20，95%CI 1.36，3.56）。一项研究评估了 IGT/DM2 的发病率，报告 DM2 发病率无显著差异（OR 2.07，95%CI 0.68，6.30）。一项研究评估了从正常糖耐量向 IGT/DM2 的转变（OR 2.4，95%CI 0.7，8.0）。没有研究报告代谢综合征的发病率。
患有 PCOS 的女性在 BMI 和非 BMI 匹配的研究中，IGT、DM2 和代谢综合征的患病率均升高。很少有研究确定患有和不患有 PCOS 的女性中 IGT/DM2 或代谢综合征的发病率，因此需要进一步研究。
