Schweitzer V G
Department of Otolaryngology-Head and Neck Surgery, Henry Ford Hospital, Detroit, MI 48202.
Otolaryngol Head Neck Surg. 1990 Mar;102(3):225-32. doi: 10.1177/019459989010200304.
Since 1975, photodynamic therapy has reportedly been effective in a variety of head and neck malignancies that failed traditional (conventional) therapy, including surgery, cryotherapy, chemotherapy, hyperthermia, and radiation therapy. Photodynamic therapy consists of the intravenous administration of (di)hematoporphyrin ether, a chemosensitizing drug selectively retained by neoplastic and reticuloendothelial tissues which, when exposed to a 630-nm argon laser, catalyzes a photochemical reaction to release free oxygen radicals, "the cytotoxic" agents responsible for cell death and tumor necrosis. Preliminary investigations have assessed the efficacy of photodynamic therapy in treatment of: (1) superficial "condemned mucosa" or "field cancerization" of the oral cavity and (2) stage III and IV head and neck carcinomas that had unsuccessful conventional therapy. Complete and/or partial remissions were obtained in 11 of 12 patients (16 treatments) with a variety of carcinomas of the nasopharynx, palate and uvula, retromolar trigone, temporal bone, cervical esophagus, and AIDS-related Kaposi's sarcoma of the oral cavity.
自1975年以来，据报道光动力疗法对多种经传统（常规）治疗（包括手术、冷冻疗法、化疗、热疗和放射治疗）失败的头颈部恶性肿瘤有效。光动力疗法包括静脉注射（二）血卟啉醚，这是一种化学增敏药物，被肿瘤组织和网状内皮组织选择性保留，当暴露于630纳米的氩激光时，催化光化学反应释放游离氧自由基，即导致细胞死亡和肿瘤坏死的“细胞毒性”物质。初步研究评估了光动力疗法在治疗以下疾病中的疗效：（1）口腔浅表的“被判死刑的黏膜”或“场癌化”；（2）传统治疗失败的III期和IV期头颈部癌。12例患者（16次治疗）患有多种鼻咽癌、腭和悬雍垂癌、磨牙后三角区癌、颞骨癌、颈段食管癌以及与艾滋病相关的口腔卡波西肉瘤，其中11例获得了完全和/或部分缓解。
