病毒丝氨酸/苏氨酸蛋白激酶。
Viral serine/threonine protein kinases.
机构信息
Department of Virology, Parasitology, and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
出版信息
J Virol. 2011 Feb;85(3):1158-73. doi: 10.1128/JVI.01369-10. Epub 2010 Nov 17.
Abstract
Phosphorylation represents one the most abundant and important posttranslational modifications of proteins, including viral proteins. Virus-encoded serine/threonine protein kinases appear to be a feature that is unique to large DNA viruses. Although the importance of these kinases for virus replication in cell culture is variable, they invariably play important roles in virus virulence. The current review provides an overview of the different viral serine/threonine protein kinases of several large DNA viruses and discusses their function, importance, and potential as antiviral drug targets.
摘要
磷酸化是蛋白质最丰富和最重要的翻译后修饰之一，包括病毒蛋白。病毒编码的丝氨酸/苏氨酸蛋白激酶似乎是大型 DNA 病毒所特有的特征。尽管这些激酶对细胞培养中病毒复制的重要性各不相同，但它们在病毒毒力中始终起着重要作用。本文综述了几种大型 DNA 病毒的不同病毒丝氨酸/苏氨酸蛋白激酶，并讨论了它们的功能、重要性及其作为抗病毒药物靶点的潜力。
相似文献
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J Virol. 2011 Feb;85(3):1158-73. doi: 10.1128/JVI.01369-10. Epub 2010 Nov 17.
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本文引用的文献
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Cyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinases.β 和 γ 亚类保守疱疹病毒蛋白激酶具有细胞周期依赖性激酶样功能。
PLoS Pathog. 2010 Sep 9;6(9):e1001092. doi: 10.1371/journal.ppat.1001092.
2
Key motifs in EBV (Epstein-Barr virus)-encoded protein kinase for phosphorylation activity and nuclear localization.EBV（Epstein-Barr 病毒）编码蛋白激酶的磷酸化活性和核定位关键基序。
Biochem J. 2010 Oct 15;431(2):227-35. doi: 10.1042/BJ20100558.
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Hyperphosphorylation of histone deacetylase 2 by alphaherpesvirus US3 kinases.α疱疹病毒 US3 激酶使组蛋白去乙酰化酶 2 过度磷酸化。
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Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo.保守的γ疱疹病毒激酶和组蛋白变体 H2AX 有助于体内γ疱疹病毒潜伏。
Virology. 2010 Sep 15;405(1):50-61. doi: 10.1016/j.virol.2010.05.027. Epub 2010 Jun 16.
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Intervirology. 2010;53(5):284-92. doi: 10.1159/000312913. Epub 2010 Jun 15.
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Further analysis of Marek's disease virus horizontal transmission confirms that U(L)44 (gC) and U(L)13 protein kinase activity are essential, while U(S)2 is nonessential.进一步分析马立克氏病病毒水平传播证实 U(L)44（gC）和 U(L)13 蛋白激酶活性是必需的，而 U(S)2 是非必需的。
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