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本文引用的文献

1
Cyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinases.β 和 γ 亚类保守疱疹病毒蛋白激酶具有细胞周期依赖性激酶样功能。
PLoS Pathog. 2010 Sep 9;6(9):e1001092. doi: 10.1371/journal.ppat.1001092.
2
Key motifs in EBV (Epstein-Barr virus)-encoded protein kinase for phosphorylation activity and nuclear localization.EBV（Epstein-Barr 病毒）编码蛋白激酶的磷酸化活性和核定位关键基序。
Biochem J. 2010 Oct 15;431(2):227-35. doi: 10.1042/BJ20100558.
3
Hyperphosphorylation of histone deacetylase 2 by alphaherpesvirus US3 kinases.α疱疹病毒 US3 激酶使组蛋白去乙酰化酶 2 过度磷酸化。
J Virol. 2010 Oct;84(19):9666-76. doi: 10.1128/JVI.00981-10. Epub 2010 Jul 21.
4
Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo.保守的γ疱疹病毒激酶和组蛋白变体 H2AX 有助于体内γ疱疹病毒潜伏。
Virology. 2010 Sep 15;405(1):50-61. doi: 10.1016/j.virol.2010.05.027. Epub 2010 Jun 16.
5
Origin and evolution of eukaryotic large nucleo-cytoplasmic DNA viruses.真核生物大核质 DNA 病毒的起源与进化。
Intervirology. 2010;53(5):284-92. doi: 10.1159/000312913. Epub 2010 Jun 15.
6
Further analysis of Marek's disease virus horizontal transmission confirms that U(L)44 (gC) and U(L)13 protein kinase activity are essential, while U(S)2 is nonessential.进一步分析马立克氏病病毒水平传播证实 U(L)44（gC）和 U(L)13 蛋白激酶活性是必需的，而 U(S)2 是非必需的。
J Virol. 2010 Aug;84(15):7911-6. doi: 10.1128/JVI.00433-10. Epub 2010 May 19.
7
Cyclin-dependent kinase inhibitors as anticancer drugs.细胞周期蛋白依赖性激酶抑制剂作为抗癌药物。
Curr Drug Targets. 2010 Mar;11(3):291-302. doi: 10.2174/138945010790711950.
8
Point mutations in BHV-1 Us3 gene abolish its ability to induce cytoskeletal changes in various cell types.牛疱疹病毒 1 型 Us3 基因的点突变使其丧失在多种细胞类型中诱导细胞骨架变化的能力。
Vet Microbiol. 2010 Jun 16;143(1):8-13. doi: 10.1016/j.vetmic.2010.02.008. Epub 2010 Feb 11.
9
VZV ORF47 serine protein kinase and its viral substrates.VZV ORF47 丝氨酸蛋白激酶及其病毒底物。
Curr Top Microbiol Immunol. 2010;342:99-111. doi: 10.1007/82_2009_5.
10
Varicella-zoster virus open reading frame 66 protein kinase and its relationship to alphaherpesvirus US3 kinases.水痘带状疱疹病毒开放阅读框 66 蛋白激酶及其与α疱疹病毒 US3 激酶的关系。
Curr Top Microbiol Immunol. 2010;342:79-98. doi: 10.1007/82_2009_7.

病毒丝氨酸/苏氨酸蛋白激酶。

Viral serine/threonine protein kinases.

机构信息

Department of Virology, Parasitology, and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.

出版信息

J Virol. 2011 Feb;85(3):1158-73. doi: 10.1128/JVI.01369-10. Epub 2010 Nov 17.

DOI:10.1128/JVI.01369-10
PMID:21084474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3020496/
Abstract

Phosphorylation represents one the most abundant and important posttranslational modifications of proteins, including viral proteins. Virus-encoded serine/threonine protein kinases appear to be a feature that is unique to large DNA viruses. Although the importance of these kinases for virus replication in cell culture is variable, they invariably play important roles in virus virulence. The current review provides an overview of the different viral serine/threonine protein kinases of several large DNA viruses and discusses their function, importance, and potential as antiviral drug targets.

摘要

磷酸化是蛋白质最丰富和最重要的翻译后修饰之一，包括病毒蛋白。病毒编码的丝氨酸/苏氨酸蛋白激酶似乎是大型 DNA 病毒所特有的特征。尽管这些激酶对细胞培养中病毒复制的重要性各不相同，但它们在病毒毒力中始终起着重要作用。本文综述了几种大型 DNA 病毒的不同病毒丝氨酸/苏氨酸蛋白激酶，并讨论了它们的功能、重要性及其作为抗病毒药物靶点的潜力。