Chan A W, Langan M C, Leong F W, Penetrante M L, Schanley D L
Research Institute on Alcoholism, New York State Division of Alcoholism and Alcohol Abuse, Buffalo 14203.
Pharmacol Biochem Behav. 1990 Feb;35(2):379-84. doi: 10.1016/0091-3057(90)90173-f.
Mice which had been fed chronically a liquid diet containing chlordiazepoxide (CDP) showed spontaneous and Ro15-1788-induced withdrawal signs upon CDP withdrawal. Ethanol (1.5 g/kg) injected 5 min before Ro15-1788 injection almost completely suppressed the withdrawal signs induced by the benzodiazepine receptor antagonist. However, neither ethanol injection nor ethanol diet administration could prevent the loss of appetite and weight loss on day 1 of CDP withdrawal. Likewise, the addition of saccharin in the ethanol diets did not prevent the loss of appetite. Mice which had been fed the CDP diet followed by 9 days of ethanol treatment (CDP/ethanol) showed more severe hypothermia during ethanol withdrawal compared to mice which had been fed the control/ethanol diets. The CDP/ethanol mice also retained the increase in runway activity attained from the prior CDP treatment. The data indicate that CDP-dependent mice showed partial rather than full cross-dependence on ethanol.
长期喂食含氯氮卓（CDP）液体饮食的小鼠在停止摄入CDP后出现了自发的以及由Ro15 - 1788诱导的戒断症状。在注射Ro15 - 1788前5分钟注射乙醇（1.5克/千克）几乎完全抑制了苯二氮䓬受体拮抗剂诱导的戒断症状。然而，无论是注射乙醇还是给予乙醇饮食都无法防止在停止摄入CDP的第1天出现食欲不振和体重减轻。同样，在乙醇饮食中添加糖精也不能防止食欲不振。与喂食对照/乙醇饮食的小鼠相比，先喂食CDP饮食然后进行9天乙醇处理（CDP/乙醇）的小鼠在乙醇戒断期间表现出更严重的体温过低。CDP/乙醇组小鼠还保留了先前CDP处理所导致的跑道活动增加。数据表明，对CDP产生依赖的小鼠对乙醇表现出部分而非完全的交叉依赖。
