Chan A W, Langan M C, Leong F W, Penetrante M L, Schanley D L, Aldrich-Castanik L
Alcohol. 1986 Sep-Oct;3(5):309-16. doi: 10.1016/0741-8329(86)90007-8.
Alcohol dependence was induced in C57BL/6J mice by administration of a liquid diet containing ethanol. These mice showed alcohol withdrawal signs when the alcohol diet was withdrawn. However, when the alcohol diet was substituted with three liquid diets containing different amounts of chlordiazepoxide (CDP; 0.4, 1 and 2 mg/ml), the alcohol withdrawal signs were fully suppressed by CDP. The CDP diet administration was continued for 14-24 days. At termination of the diet treatment, the mice showed CDP withdrawal signs. Similar signs, but much more short-lived, can be precipitated by injection of the benzodiazepine receptor antagonist, RO-15-1788. The results are consistent with the hypothesis that alcohol-dependent mice are cross-dependent on CDP. This report constitutes the first experimental demonstration of cross-dependence between ethanol and CDP. The reverse phenomenon, namely, CDP-dependent mice being cross-dependent on ethanol, remains to be investigated.
通过给予含乙醇的液体饲料，在C57BL/6J小鼠中诱导产生酒精依赖。当撤掉酒精饲料时，这些小鼠出现了酒精戒断症状。然而，当用三种含有不同剂量氯氮卓（CDP；0.4、1和2毫克/毫升）的液体饲料替代酒精饲料时，酒精戒断症状被CDP完全抑制。CDP饲料给药持续14至24天。在饮食治疗结束时，小鼠出现了CDP戒断症状。注射苯二氮卓受体拮抗剂RO-15-1788可引发类似但持续时间短得多的症状。这些结果与酒精依赖小鼠对CDP产生交叉依赖的假说一致。本报告首次通过实验证明了乙醇与CDP之间的交叉依赖。乙醇依赖小鼠对CDP产生交叉依赖这一相反现象仍有待研究。
