Arranz Peña M I, Seijas Martínez-Echevarría M V, Aguado-Vega M, Rubí Cervino J
Hospital Ramón y Cajal de la Seguridad Social, Madrid.
Rev Clin Esp. 1990 Jan;186(1):19-22.
This study reveals the efficiency of phenobarbital, diphenilhidantoine, carbamazepine, valproic acid and teophyline serum levels for their correct adjustment within the concentration gap considered optimal to produce the desired pharmacological effect. A total population of 882 patients treated with the drugs previously named is studied and an important improvement in dose adjustment is observed during these years as a consequence of drug's serum level knowledge.
本研究揭示了苯巴比妥、苯妥英钠、卡马西平、丙戊酸和茶碱血清水平在其被认为能产生所需药理作用的最佳浓度范围内进行正确调整的有效性。对总共882名接受上述药物治疗的患者进行了研究，由于掌握了药物的血清水平，这些年来在剂量调整方面有了显著改善。
