Li Jiarong, Chen Xian, Shi Daxin, Ma Shuling, Li Qing, Zhang Qi, Tang Jianhong
School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing, PR China 100081.
Org Lett. 2009 Mar 19;11(6):1193-6. doi: 10.1021/ol900093h.
A new and facile preparation of quinazoline-2,4(1H,3H)-diones was first reported which was the condensation of aromatic o-aminonitriles with DMF or N,N-diethylformamide in the presence of ZnCl(2) (0.5-10 mol %) at 190-200 degrees C in the sealed reactor.
首次报道了一种新型且简便的喹唑啉-2,4(1H,3H)-二酮的制备方法，该方法是在密封反应器中，于190 - 200℃下，在0.5 - 10 mol%的ZnCl₂存在下，使芳香邻氨基腈与DMF或N,N-二乙基甲酰胺发生缩合反应。
