Maimonides Medical Center, 4802 Tenth Avenue, Brooklyn, NY 11219, USA.
Curr Diab Rep. 2011 Feb;11(1):56-63. doi: 10.1007/s11892-010-0163-x.
Diabetes has emerged as the modern day epidemic that is currently affecting over 220 million people worldwide and claiming at least 1.1 million lives in 2005 alone. The rise in diabetes is largely attributed to the epidemic of obesity together with sedentary lifestyle as well as unhealthy dietary habits. Despite evidence that glycemic control as well as control of other cardiovascular disease (CVD) risk factors such as hypertension and dyslipidemia decreases morbidity and mortality in the diabetic population, control of glycemia and other CVD risk factors remains largely suboptimal making the concept of prevention of diabetes very appealing to control CVD risk, especially that such a risk is already increased in people in the prediabetic stage. Several large controlled trials have been completed testing various options for diabetes prevention. In this paper we present an update on prevention of type 2 diabetes highlighting the major recent trials completed to date in this very important area of investigation.
糖尿病已成为现代流行疾病，目前全球有超过 2.2 亿人受其影响，仅 2005 年就有至少 110 万人因此死亡。糖尿病发病率的上升在很大程度上归因于肥胖症的流行以及久坐不动的生活方式和不健康的饮食习惯。尽管有证据表明，控制血糖以及控制高血压和血脂异常等其他心血管疾病（CVD）风险因素可降低糖尿病患者的发病率和死亡率，但血糖控制和其他 CVD 风险因素的控制仍远不理想，这使得预防糖尿病的概念非常吸引人，可以控制 CVD 风险，特别是在糖尿病前期人群中，这种风险已经增加。已经完成了几项大型对照试验来测试预防糖尿病的各种选择。在本文中，我们介绍了预防 2 型糖尿病的最新进展，重点介绍了迄今为止在这一重要研究领域完成的主要最新试验。
