Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, Bethesda, Maryland, USA.
Infect Agent Cancer. 2010 Nov 18;5:21. doi: 10.1186/1750-9378-5-21.
Kaposi sarcoma-associated herpesvirus (KSHV, also called Human herpesvirus 8 or HHV8) is a γ-2 herpesvirus that causes Kaposi sarcoma. KSHV seroprevalence rates vary geographically with variable rates recorded in different sub Sahara African countries, suggesting that effects of genetic and/or environmental factors may influence the risk of infection. One study conducted in South Africa, where KSHV seroprevalence is relatively low, found that carriage of human leukocyte antigen (HLA) alleles HLA-A6801, HLA-A30, HLA-A4301, and HLA-DRB104 was associated with increased shedding of KSHV DNA in saliva. Confirmation of those results would strengthen the hypothesis that genetic factors may influence KSHV distribution by modulating KSHV shedding in saliva. To explore these associations in another setting, we used high resolution HLA-A, B, and DRB1 typing on residual samples from the Uganda Sickle Cell Anemia KSHV study, conducted in a high KSHV seroprevalence region, to investigate associations between HLA and KSHV shedding in saliva or peripheral blood among 233 children and their mothers. HLA-A and HLA-DRB1 alleles were not associated with KSHV shedding in our study, but our study was small and was not adequately powered to exclude small associations. In exploratory analyses, we found marginal association of KSHV DNA shedding in saliva but not in peripheral blood among children carrying HLA- B4415 and marginal association of KSHV DNA shedding in peripheral blood but not in saliva among children carrying HLA- B0801 alleles. The contribution of individual HLA polymorphisms to KSHV shedding is important but it may vary in different populations. Larger population-based studies are needed to estimate the magnitude and direction of association of HLA with KSHV shedding and viral control.
卡波济肉瘤相关疱疹病毒（KSHV，也称为人类疱疹病毒 8 或 HHV8）是一种 γ-2 疱疹病毒，可引起卡波济肉瘤。KSHV 的血清流行率因地理位置而异，不同撒哈拉以南非洲国家的记录率存在差异，这表明遗传和/或环境因素的影响可能会影响感染的风险。在南非进行的一项研究中，KSHV 的血清流行率相对较低，研究发现携带人类白细胞抗原（HLA）等位基因 HLA-A6801、HLA-A30、HLA-A4301 和 HLA-DRB104 与唾液中 KSHV DNA 的脱落增加有关。这些结果的证实将加强遗传因素可能通过调节唾液中 KSHV 的脱落来影响 KSHV 分布的假设。为了在另一种环境中探索这些关联，我们使用高分辨率 HLA-A、B 和 DRB1 分型对在高 KSHV 血清流行率地区进行的乌干达镰状细胞贫血 KSHV 研究中的剩余样本进行分析，以研究 HLA 与唾液或外周血中 KSHV 脱落之间的关联在 233 名儿童及其母亲中。在我们的研究中，HLA-A 和 HLA-DRB1 等位基因与 KSHV 的脱落无关，但我们的研究规模较小，没有足够的能力排除小关联。在探索性分析中，我们发现携带 HLA-B4415 的儿童唾液中 KSHV DNA 脱落呈边缘关联，但外周血中无关联，携带 HLA-B0801 等位基因的儿童外周血中 KSHV DNA 脱落呈边缘关联，但唾液中无关联。个体 HLA 多态性对 KSHV 脱落的贡献很重要，但在不同人群中可能有所不同。需要更大的基于人群的研究来估计 HLA 与 KSHV 脱落和病毒控制的关联程度和方向。
