Jenkins P J, Harper R W, Nestel P J
Br Med J. 1978 Aug 5;2(6134):388-91. doi: 10.1136/bmj.2.6134.388.
The influence of individual lipoproteins on the severity of coronary atherosclerosis was studied in 41 patients undergoing coronary angiography. The extent of athero-sclerosis was quantified by a coronary atherosclerosis score (CAS) based on the number and severity of lesions in eight proximal segments of the coronary circulation. The concentration of high-density lipoprotein (HDL) showed a strong inverse association with CAS, which was independent of the effects of age and other lipoproteins. On multivariate analysis concentrations of other lipids--namely, total plasma cholesterol, low-density lipoprotein (LDL) cholesterol, and the combined effect of LDL cholesterol plus very-low-density lipoprotein triglyceride--showed direct, significant correlations with CAS, but these were weaker than that of HDL. This study shows that concentrations of several circulating lipoproteins are related to the severity of coronary atherosclerosis, HDL having an apparent retarding effect. These findings may partly explain the influence of lipoproteins on the development of clinical coronary heart disease.
在41例接受冠状动脉造影的患者中,研究了个体脂蛋白对冠状动脉粥样硬化严重程度的影响。动脉粥样硬化的程度通过冠状动脉粥样硬化评分(CAS)进行量化,该评分基于冠状动脉循环八个近端节段中病变的数量和严重程度。高密度脂蛋白(HDL)浓度与CAS呈强烈负相关,且不受年龄和其他脂蛋白影响。多变量分析显示,其他脂质的浓度,即总血浆胆固醇、低密度脂蛋白(LDL)胆固醇以及LDL胆固醇与极低密度脂蛋白甘油三酯的联合作用,与CAS呈直接显著相关,但这些相关性比HDL与CAS的相关性弱。本研究表明,几种循环脂蛋白的浓度与冠状动脉粥样硬化的严重程度相关,HDL具有明显的延缓作用。这些发现可能部分解释了脂蛋白对临床冠心病发展的影响。