University Hospital, Psychiatry Service, Universidade Federal da Bahia, Salvador, Brazil.
Compr Psychiatry. 2011 Jul-Aug;52(4):386-93. doi: 10.1016/j.comppsych.2010.09.006. Epub 2010 Nov 18.
Although major depressive disorder (MDD) has been consistently considered the most frequent complication of obsessive-compulsive disorder (OCD), little is known about the clinical characteristics of patients with both disorders. This study assessed 815 Brazilian OCD patients using a comprehensive psychiatric evaluation. Clinical and demographic variables, including OCD symptom dimensions, were compared among OCD patients with and without MDD. Our findings showed that prevalence rates of current MDD (32%) and lifetime MDD (67.5%) were similar for both sexes in this study. In addition, patients with comorbid MDD had higher severity scores of OCD symptoms. There was no preferential association of MDD with any particular OCD symptom dimension. This study supports the notion that depressed OCD patients present more severe general psychopathology.
尽管重度抑郁症（MDD）一直被认为是强迫症（OCD）最常见的并发症，但对于同时患有这两种疾病的患者的临床特征知之甚少。本研究使用全面的精神病学评估对 815 名巴西 OCD 患者进行了评估。比较了 OCD 患者伴或不伴 MDD 的临床和人口统计学变量，包括 OCD 症状维度。我们的研究结果表明，在这项研究中，男性和女性的当前 MDD（32%）和终生 MDD（67.5%）的患病率相似。此外，合并 MDD 的患者的 OCD 症状严重程度评分更高。MDD 与任何特定的 OCD 症状维度没有优先关联。本研究支持这样一种观点，即患有抑郁的 OCD 患者表现出更严重的一般精神病理学。
