Department of Ophthalmology, Dokkyo Medical University, Tochigi, Japan.
Ophthalmic Res. 2011;45(4):216-20. doi: 10.1159/000321533. Epub 2010 Nov 17.
We investigated the developmental factors of fibrous opacification in the atopic cataract lens capsule.
We examined the expression of transforming growth factor (TGF)-β signals (phosphorylated Smad2/3 and Smad7) and plasminogen activator inhibitor (PAI)-1 in atopic cataract lenses by immunohistochemistry. The PAI-1 concentration in aqueous humor was also measured.
Lens epithelial cells of the atopic cataract lens capsule showed positive immunohistochemical staining for phosphorylated Smad2/3 and Smad7. Lens epithelial cells of the age-related cataract lens capsule were positive for phosphorylated Smad2/3, but negative for Smad7 by immunohistochemistry. All cells were negative for PAI-1. However, high concentrations of PAI-1 were detected in the aqueous humor of atopic cataract patients.
We suggest that TGF-β and PAI-1 contribute to fibrous opacification in the atopic cataract lens capsule.
我们研究了特应性白内障晶状体囊纤维混浊的发育因素。
我们通过免疫组织化学方法检测了特应性白内障晶状体中转化生长因子 (TGF)-β信号（磷酸化 Smad2/3 和 Smad7）和纤溶酶原激活物抑制剂 (PAI)-1 的表达。还测量了房水中的 PAI-1 浓度。
特应性白内障晶状体囊的晶状体上皮细胞呈磷酸化 Smad2/3 和 Smad7 免疫组织化学阳性。年龄相关性白内障晶状体囊的晶状体上皮细胞磷酸化 Smad2/3 阳性，但 Smad7 阴性。所有细胞均为 PAI-1 阴性。然而，在特应性白内障患者的房水中检测到高浓度的 PAI-1。
我们认为 TGF-β和 PAI-1 有助于特应性白内障晶状体囊的纤维混浊。
