Illawarra Cancer Care Centre (ICCC), Wollongong, New South Wales 2500, Australia.
Med Phys. 2010 Oct;37(10):5208-17. doi: 10.1118/1.3488980.
The main focus of this work is to continue investigations into the Monte Carlo predicted skin doses seen in MRI-guided radiotherapy. In particular, the authors aim to characterize the 70 microm skin doses over a larger range of magnetic field strength and x-ray field size than in the current literature. The effect of surface orientation on both the entry and exit sides is also studied. Finally, the use of exit bolus is also investigated for minimizing the negative effects of the electron return effect (ERE) on the exit skin dose.
High resolution GEANT4 Monte Carlo simulations of a water phantom exposed to a 6 MV x-ray beam (Varian 2100C) have been performed. Transverse magnetic fields of strengths between 0 and 3 T have been applied to a 30 x 30 x 20 cm3 phantom. This phantom is also altered to have variable entry and exit surfaces with respect to the beam central axis and they range from -75 degrees to +75 degrees. The exit bolus simulated is a 1 cm thick (water equivalent) slab located on the beam exit side.
On the entry side, significant skin doses at the beam central axis are reported for large positive surface angles and strong magnetic fields. However, over the entry surface angle range of -30 degrees to -60 degrees, the entry skin dose is comparable to or less than the zero magnetic field skin dose, regardless of magnetic field strength and field size. On the exit side, moderate to high central axis skin dose increases are expected except at large positive surface angles. For exit bolus of 1 cm thickness, the central axis exit skin dose becomes an almost consistent value regardless of magnetic field strength or exit surface angle. This is due to the almost complete absorption of the ERE electrons by the bolus.
There is an ideal entry angle range of -30 degrees to -60 degrees where entry skin dose is comparable to or less than the zero magnetic field skin dose. Other than this, the entry skin dose increases are significant, especially at higher magnetic fields. On the exit side there is mostly moderate to high skin dose increases for 0.2-3 T with the only exception being large positive angles. Exit bolus of 1 cm thickness will have a significant impact on lowering such exit skin dose increases that occur as a result of the ERE.
本工作的主要重点是继续研究 MRI 引导放疗中观察到的蒙特卡罗预测皮肤剂量。特别是,作者旨在比当前文献更广泛地研究磁场强度和 X 射线场尺寸范围内的 70μm 皮肤剂量。还研究了表面方向对入射侧和出射侧的影响。最后,还研究了使用出射增感来最小化电子返回效应(ERE)对出射皮肤剂量的负面影响。
对暴露于 6 MV X 射线束(瓦里安 2100C)的水模体进行了高分辨率 GEANT4 蒙特卡罗模拟。应用强度在 0 到 3 T 之间的横向磁场。该体模还被改变为具有相对于射束中心轴的可变入射和出射表面,范围从-75 度到+75 度。模拟的出射增感是位于射束出射侧的 1cm 厚(水当量)平板。
在入射侧,对于大的正表面角度和强磁场,报告了在射束中心轴上的显著皮肤剂量。然而,在入射表面角度范围为-30 度至-60 度时,无论磁场强度和场尺寸如何,入射皮肤剂量与零磁场皮肤剂量相当或小于零磁场皮肤剂量。在出射侧,除了在大的正表面角度外,预计将有适度至高的中心轴皮肤剂量增加。对于 1cm 厚的出射增感,中心轴出射皮肤剂量成为一个几乎不变的值,无论磁场强度或出射表面角度如何。这是由于 ERE 电子几乎完全被增感所吸收。
存在一个理想的入射角度范围,在该范围内,入射皮肤剂量与零磁场皮肤剂量相当或小于零磁场皮肤剂量。除此之外,入射皮肤剂量增加是显著的,尤其是在更高的磁场下。在出射侧,0.2-3T 时,大多数情况下皮肤剂量会适度增加,只有在大的正角度时例外。1cm 厚的出射增感将对降低由于 ERE 而导致的出射皮肤剂量增加产生重大影响。