NHC 催化的通过串联 Stetter-aldol-Michael 和 Stetter-aldol-aldol 反应的螺双茚满形成反应。
NHC-catalyzed spiro bis-indane formation via domino Stetter-aldol-Michael and Stetter-aldol-aldol reactions.
机构信息
Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
出版信息
Org Lett. 2010 Dec 17;12(24):5772-5. doi: 10.1021/ol102685u. Epub 2010 Nov 22.
PMID:21090705
Abstract
Two novel domino NHC-catalyzed spirocyclizations are described herein, enabling the rapid construction of three new carbon-carbon bonds and a quaternary center with high diastereoselectivity. A variety of spiro bis-indane structures are assembled in a single step from simple o-phthaldialdehyde derivatives.
摘要
本文描述了两种新型的多米诺 NHC 催化的螺环化反应，能够以高非对映选择性快速构建三个新的碳-碳键和一个季碳原子。通过简单的邻苯二甲醛衍生物可以在一步反应中组装各种螺双茚满结构。
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