Walia Saloni, Clermont Allen C, Gao Ben-Bo, Aiello Lloyd Paul, Feener Edward P
Joslin Diabetes Center, Boston, MA, USA.
Semin Ophthalmol. 2010 Sep-Nov;25(5-6):289-94. doi: 10.3109/08820538.2010.518912.
Diabetic retinopathy is the major cause of acquired blindness in working-age adults. Studies of the vitreous proteome have provided insights into the etiology of diabetic retinopathy and suggested potential molecular targets for treatments. Further characterization of the protein changes associated with the progression of this disease may suggest additional therapeutic approaches as well as reveal novel factors that may be useful in predicting risk and functional outcomes of interventional therapies. This article provides an overview of the various techniques used for proteomic analysis of the vitreous and details results from various studies evaluating vitreous of diabetic patients using the proteomic approach.
糖尿病视网膜病变是工作年龄成年人后天失明的主要原因。对玻璃体蛋白质组的研究为糖尿病视网膜病变的病因提供了见解，并提出了潜在的治疗分子靶点。对与该疾病进展相关的蛋白质变化进行进一步表征，可能会提出额外的治疗方法，并揭示可能有助于预测介入治疗风险和功能结果的新因素。本文概述了用于玻璃体蛋白质组分析的各种技术，并详细介绍了使用蛋白质组学方法评估糖尿病患者玻璃体的各项研究结果。
