Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Immunotherapy. 2010 Nov;2(6):791-4. doi: 10.2217/imt.10.73.
Evaluation of: Bendle GM, Linnemann C, Hooijkaas AI et al.: Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy. Nat. Med. 16(5), 565-570 (2010). Graft-versus-host disease is commonly associated with allogeneic hematopoietic cell transplantation, as it is the major complication. This article reports that, after immunotherapy with lymphocytes that have been transduced with T-cell receptor (TCR) genes of known specificity, graft-versus-host disease can occur through TCR gene transfer. This autoimmune pathology occurs through the formation of self-reactive TCRs as a result of one chain of the transduced TCR cross-pairing with an endogenous TCR. Certain adjustments in the design of gene therapy vectors may help reduce the risk of such autoimmune phenomena.
Bendle GM、Linnemann C、Hooijkaas AI 等人：T 细胞受体基因治疗小鼠模型中的致命移植物抗宿主病。自然医学 16(5), 565-570 (2010)。移植物抗宿主病通常与同种异体造血细胞移植相关，因为它是主要并发症。本文报道，在用已知特异性 T 细胞受体 (TCR) 基因转导的淋巴细胞进行免疫治疗后，移植物抗宿主病可能通过 TCR 基因转移发生。这种自身免疫病理学是由于转导的 TCR 的一条链与内源性 TCR 交叉配对而形成自身反应性 TCR 所致。基因治疗载体设计的某些调整可能有助于降低此类自身免疫现象的风险。
