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Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.
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PXR/CYP3A4-humanized mice for studying drug-drug interactions involving intestinal P-glycoprotein.
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Role of pregnane X receptor in obesity and glucose homeostasis in male mice.
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Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice.
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Functional evolution of the pregnane X receptor.
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Mechanisms and Therapeutic Advances of PXR in Metabolic Diseases and Cancer.
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Impact of sex and pregnancy on hepatic CYP3A4 expression and activity in a humanized mouse model.
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Activation of PXR causes drug interactions with Paxlovid in transgenic mice.
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Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels.
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Arsenic Metabolism in Mice Carrying a Locus Humanized by Syntenic Replacement.
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CITCO Directly Binds to and Activates Human Pregnane X Receptor.
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Pregnane X receptor is SUMOylated to repress the inflammatory response.
J Pharmacol Exp Ther. 2010 Nov;335(2):342-50. doi: 10.1124/jpet.110.171744. Epub 2010 Aug 18.
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Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation.
J Pharmacol Exp Ther. 2010 Oct;335(1):32-41. doi: 10.1124/jpet.110.170225. Epub 2010 Jul 13.
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A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling.
J Biol Chem. 2010 Sep 3;285(36):28097-104. doi: 10.1074/jbc.M110.116566. Epub 2010 Jun 17.
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Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding.
Biochem Biophys Res Commun. 2010 Mar 19;393(4):688-93. doi: 10.1016/j.bbrc.2010.02.058. Epub 2010 Feb 18.
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Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR.
PLoS Comput Biol. 2009 Dec;5(12):e1000594. doi: 10.1371/journal.pcbi.1000594. Epub 2009 Dec 11.
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Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.
Cancer Res. 2009 Dec 1;69(23):8996-9002. doi: 10.1158/0008-5472.CAN-09-2915. Epub 2009 Nov 17.
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The structural basis of pregnane X receptor binding promiscuity.
Biochemistry. 2009 Dec 8;48(48):11572-81. doi: 10.1021/bi901578n.
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Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity.
Drug Metab Dispos. 2009 Aug;37(8):1611-21. doi: 10.1124/dmd.109.027565. Epub 2009 May 21.

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