Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, PA 19348, USA.
J Vet Intern Med. 2011 May-Jun;25(3):570-4. doi: 10.1111/j.1939-1676.2010.0641.x. Epub 2010 Nov 23.
Central venous pressure (CVP) is used in many species to monitor right-sided intravascular volume status, especially in critical care medicine.
That hypohydration in adult horses is associated with a proportional reduction in CVP.
Ten healthy adult horses from the university teaching herd.
In this experimental study, horses underwent central venous catheter placement and CVP readings were obtained by water manometry. The horses were then deprived of water and administered furosemide (1 mg/kg IV q6h) for up to 36 hours. Weight, CVP, vital signs, PCV, total protein (TP), and serum lactate were monitored at baseline and every 6 hours until a target of 5% decrease in body weight loss was achieved. The spleen volume was estimated sonographically at baseline and peak volume depletion. Linear regression analysis was used to assess the association of CVP and other clinical parameters with degree of body weight loss over time.
There was a significant association between CVP and decline in body weight (P < .001), with a decrease in CVP of 2.2 cmH(2)O for every percentage point decrease in body weight. Other significant associations between volume depletion and parameters measured included increased TP (P = .007), increased serum lactate concentration (P = .048), and decreased splenic volume (P = .046). There was no significant association between CVP and vital signs or PCV.
These findings suggest that CVP monitoring might be a useful addition to the clinical evaluation of hydration status in adult horses.
中心静脉压（CVP）在许多物种中用于监测右侧血管内容量状态，尤其是在重症监护医学中。
成年马脱水与 CVP 成比例降低有关。
大学教学马群中的 10 匹健康成年马。
在这项实验研究中，马接受了中心静脉导管放置，通过水压计获得 CVP 读数。然后，马被剥夺水分，并给予呋塞米（1 毫克/千克 IV q6h）长达 36 小时。体重、CVP、生命体征、PCV、总蛋白（TP）和血清乳酸在基线和每 6 小时监测一次，直到体重减轻 5%的目标达到。在基线和峰值容量耗竭时通过超声估计脾脏体积。线性回归分析用于评估 CVP 和其他临床参数与随时间推移的体重减轻程度之间的关联。
CVP 与体重下降之间存在显著关联（P <.001），体重每下降 1%，CVP 下降 2.2cmH(2)O。容量耗竭与测量的参数之间的其他显著关联包括 TP 增加（P =.007）、血清乳酸浓度增加（P =.048）和脾脏体积减少（P =.046）。CVP 与生命体征或 PCV 之间无显著关联。
这些发现表明，CVP 监测可能是评估成年马水合状态的临床评估的有用补充。
