Brophy Sinead, Davies Helen, Stephens Jeffrey W, Prior Sarah L, Atkinson Mark, Bain Stephen, Williams Rhys
Senior Lecturer in Epidemiology and Public Health, College of Medicine, Swansea University, Swansea, SA2 8PP UK.
BMC Res Notes. 2010 Nov 22;3:317. doi: 10.1186/1756-0500-3-317.
To examine adiponectin levels in people with Latent Autoimmune Diabetes in Adults using a matched pair case control study.
Patients with LADA (n = 64), were matched for sex with type 2 diabetic and non-diabetic controls. A matched paired T-test was used to examine average adiponectin levels in the LADA patients' versus controls. The average adiponectin level for the LADA patients was 9.96 μg/ml compared to 6.4 μg/ml for Type 2 matched controls and 9.6 μg/ml for non-diabetic controls. Mean difference for the LADA-type 2 comparison was calculated after data was log transformed and showed a difference of 1.58 μg/ml (95%CI: 1.28-1.95, p = 0.0001). There was no significant difference between LADA and non-diabetic controls (p = 0.54).
Adiponectin levels are higher among people with LADA compared to those with type 2 diabetes and are equivalent to levels seen in non-diabetic controls. This suggests that risk of complications in LADA, as with type 1 diabetes may be related more to glycaemic control rather than to factors of the metabolic syndrome.
采用配对病例对照研究来检测成人隐匿性自身免疫性糖尿病患者的脂联素水平。
成人隐匿性自身免疫性糖尿病患者（n = 64）与2型糖尿病患者及非糖尿病对照者按性别进行配对。采用配对t检验来检测成人隐匿性自身免疫性糖尿病患者与对照者的平均脂联素水平。成人隐匿性自身免疫性糖尿病患者的平均脂联素水平为9.96μg/ml，而2型糖尿病配对对照者为6.4μg/ml，非糖尿病对照者为9.6μg/ml。对数据进行对数转换后计算成人隐匿性自身免疫性糖尿病患者与2型糖尿病患者之间的平均差异，结果显示差异为1.58μg/ml（95%置信区间：1.28 - 1.95，p = 0.0001）。成人隐匿性自身免疫性糖尿病患者与非糖尿病对照者之间无显著差异（p = 0.54）。
与2型糖尿病患者相比，成人隐匿性自身免疫性糖尿病患者的脂联素水平更高，且与非糖尿病对照者的水平相当。这表明，与1型糖尿病一样，成人隐匿性自身免疫性糖尿病并发症的风险可能更多地与血糖控制有关，而非代谢综合征因素。
