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用N-亚硝基双（2-氧代丙基）胺处理的豚鼠胆管和肝脏肿瘤的发生

Development of biliary and hepatic neoplasms in guinea pigs treated with N-nitrosobis(2-oxopropyl)amine.

作者信息

Rao M S, Pour P

出版信息

Cancer Lett. 1978 Jul;5(1):31-4. doi: 10.1016/s0304-3835(78)80007-x.

DOI:10.1016/s0304-3835(78)80007-x
PMID:210926
Abstract

N-Nitrosobis(2-oxopropyl)amine (BOP) was administered subcutaneously to 29 male inbred strain 13 guinea pigs at weekly intervals for 4 weeks. The guinea pigs were observed until their death or termination of the experiment at the end of 55 weeks. Of 14 guinea pigs that survived more than 30 weeks, 7 animals developed cholangiocarcinomas and 2 developed hepatocellular carcinomas. Tumors of other sites were not found.

摘要

将N-亚硝基双（2-氧代丙基）胺（BOP）每周一次皮下注射给29只雄性近交系13豚鼠，持续4周。观察这些豚鼠直至其死亡或在55周结束时实验终止。在存活超过30周的14只豚鼠中，7只动物发生了胆管癌，2只发生了肝细胞癌。未发现其他部位的肿瘤。

相似文献

1
Development of biliary and hepatic neoplasms in guinea pigs treated with N-nitrosobis(2-oxopropyl)amine.用N-亚硝基双（2-氧代丙基）胺处理的豚鼠胆管和肝脏肿瘤的发生
Cancer Lett. 1978 Jul;5(1):31-4. doi: 10.1016/s0304-3835(78)80007-x.
2
The effect of N-nitrosobis(2-oxopropyl)amine after oral administration to hamsters.N-亚硝基双（2-氧代丙基）胺经口给予仓鼠后的效应。
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3
Cycles of repeated augmentation pressure in rapid production of pancreatic and cholangiocellular carcinomas in hamsters initiated with N-nitrosobis(2-oxopropyl)amine.
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4
Effects of phenobarbital and secondary bile acids on liver, gallbladder, and pancreas carcinogenesis initiated by N-nitrosobis (2-hydroxypropyl)amine in hamsters.苯巴比妥和次级胆汁酸对N-亚硝基双（2-羟丙基）胺引发的仓鼠肝脏、胆囊和胰腺致癌作用的影响。
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Induction of malignant vascular tumors of the liver in guinea pigs treated with 2,2'-dihydroxy-di-n-propylnitrosamine.用2,2'-二羟基二正丙基亚硝胺处理的豚鼠肝脏恶性血管肿瘤的诱导。
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Induction of exocrine pancreatic, bile duct, and thyroid gland tumors in offspring of Syrian hamsters treated with N-nitrosobis(2-oxopropyl)amine during pregnancy.孕期用N-亚硝基双（2-氧代丙基）胺处理的叙利亚仓鼠后代中胰腺外分泌腺、胆管和甲状腺肿瘤的诱发
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Effects of N-nitrosobis(2-oxopropyl)amine in newborn and suckling hamsters.N-亚硝基双（2-氧代丙基）胺对新生和哺乳仓鼠的影响。
Br J Cancer. 1980 Jun;41(6):996-9. doi: 10.1038/bjc.1980.181.
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A potent pancreatic carcinogen in Syrian hamsters: N-nitrosobis(2-oxopropyl)amine.叙利亚仓鼠体内一种强效的胰腺癌致癌物：N-亚硝基双（2-氧代丙基）胺。
J Natl Cancer Inst. 1977 May;58(5):1449-53. doi: 10.1093/jnci/58.5.1449.
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Carcinogenic effect of N-nitrosobis (2-oxopropyl)amine in newborn rats.N-亚硝基双（2-氧代丙基）胺对新生大鼠的致癌作用。
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Induction of local epidermal papillomas and carcinoma by selected nitrosamines.特定亚硝胺诱发局部表皮乳头瘤和癌
Cancer Lett. 1980 Oct;10(4):365-73. doi: 10.1016/0304-3835(80)90055-5.

引用本文的文献

1
Effects of N-nitrosobis(2-oxopropyl)amine in newborn and suckling hamsters.N-亚硝基双（2-氧代丙基）胺对新生和哺乳仓鼠的影响。
Br J Cancer. 1980 Jun;41(6):996-9. doi: 10.1038/bjc.1980.181.