In vitro reaction of radioactive 7beta, 8alpha, --dihydroxy--9alpha, 10alpha-epoxy--7,8,9,10--tetrahydrobenzo (A) pyrene and 7beta,8alpha--dihydroxy--9beta, 10beta--epoxy--7,8,9,10--tetrahydrobenzo (A) pyrene with DNA.
作者信息
Remsen J, Jerina D, Yagi H, Cerutti P
出版信息
Biochem Biophys Res Commun. 1977 Feb 7;74(3):934-40. doi: 10.1016/0006-291x(77)91608-4.
PMID:320977
Abstract
摘要
相似文献
1
In vitro reaction of radioactive 7beta, 8alpha, --dihydroxy--9alpha, 10alpha-epoxy--7,8,9,10--tetrahydrobenzo (A) pyrene and 7beta,8alpha--dihydroxy--9beta, 10beta--epoxy--7,8,9,10--tetrahydrobenzo (A) pyrene with DNA.放射性7β, 8α - 二羟基 - 9α, 10α - 环氧 - 7,8,9,10 - 四氢苯并(A)芘和7β,8α - 二羟基 - 9β, 10β - 环氧 - 7,8,9,10 - 四氢苯并(A)芘与DNA的体外反应
Biochem Biophys Res Commun. 1977 Feb 7;74(3):934-40. doi: 10.1016/0006-291x(77)91608-4.
2
Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.非对映体苯并[a]芘7,8 - 二醇 - 9,10 - 环氧化物光学对映体在新生小鼠中的致瘤性：(+)-7β,8α - 二羟基 - 9α,10α - 环氧 - 7,8,9,10 - 四氢苯并[a]芘的异常活性
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5358-61. doi: 10.1073/pnas.75.11.5358.
3
Comparison of the tumor-initiating activities of benzo(a)pyrene arene oxides and diol-epoxides.苯并(a)芘芳烃氧化物和二醇环氧化物的肿瘤起始活性比较。
Cancer Res. 1977 Nov;37(11):4130-3.
4
Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice.苯并(a)芘二醇环氧化物的致癌性研究表明，(±)-反式-7β,8α-二羟基-9α,10α-环氧-7,8,9,10-四氢苯并(a)芘是新生小鼠的一种最终致癌物。
Cancer Res. 1978 Feb;38(2):354-8.
5
Carcinogenicity of benzo-ring derivatives of benzo(a)pyrene on mouse skin.苯并(a)芘的苯环衍生物对小鼠皮肤的致癌性。
Cancer Res. 1977 Sep;37(9):3356-61.
6
7
Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.苯并(a)芘苯环环氧化物的致突变性和细胞毒性。
Cancer Res. 1976 Sep;36(9 pt.1):3358-66.
8
(+/-)-7alpha,8beta-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)-pyrene is an intermediate in the metabolism and binding to DNA of benzo(a)pyrene.（±）-7α，8β-二羟基-9β，10β-环氧-7,8,9,10-四氢苯并（a）芘是苯并（a）芘代谢及与DNA结合过程中的一种中间体。
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2679-81. doi: 10.1073/pnas.73.8.2679.
9
Alkylation of polyguanylic acid at the 2-amino group and phosphate by the potent mutagen (+/-)-7beta,8alpha-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.强效诱变剂（±）-7β,8α-二羟基-9β,10β-环氧-7,8,9,10-四氢苯并[a]芘对聚鸟苷酸2-氨基和磷酸基团的烷基化作用
J Am Chem Soc. 1976 Oct 13;98(21):6720-2. doi: 10.1021/ja00437a061.
10
Letter: Synthesis of (+/-)-7 beta,8alpha-dihydroxy-9 beta,10beta-epoxy-7,8,-9,10-tetrahydrobenzo(a)pyrene, a potential metabolite of the carcinogen benzo(a)pyrene with stereochemistry related to the antileukemic triptolides.信函：（±）-7β，8α-二羟基-9β，10β-环氧-7,8,-9,10-四氢苯并（a）芘的合成，苯并（a）芘的一种潜在代谢产物，其立体化学与抗白血病雷公藤内酯醇相关 。
J Am Chem Soc. 1975 Nov 12;97(23):6881-3. doi: 10.1021/ja00856a057.
引用本文的文献
1
Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.非对映体苯并[a]芘7,8 - 二醇 - 9,10 - 环氧化物光学对映体在新生小鼠中的致瘤性：(+)-7β,8α - 二羟基 - 9α,10α - 环氧 - 7,8,9,10 - 四氢苯并[a]芘的异常活性
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5358-61. doi: 10.1073/pnas.75.11.5358.
2
Excision repair of benzo[a]pyrene-deoxyguanosine adducts in baby hamster kidney 21/C13 cells and in secondary mouse embryo fibroblasts C57BL/6J.在幼仓鼠肾21/C13细胞和二代小鼠胚胎成纤维细胞C57BL/6J中苯并[a]芘-脱氧鸟苷加合物的切除修复
Proc Natl Acad Sci U S A. 1977 Mar;74(3):979-83. doi: 10.1073/pnas.74.3.979.
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