Institute for Microelectronics and Microsystems-Rome, Via Fosso del Cavaliere 100, 00133 Rome, Italy.
Biosens Bioelectron. 2011 Jan 15;26(5):2460-5. doi: 10.1016/j.bios.2010.10.032. Epub 2010 Oct 27.
The aim of the present study is to combine a bio-inspired nanofibrous artificial epithelium to the electronic nose (e-nose) principles. The sensing device set up was an electronic nose consisting of an array of 9 micro-chemoresistors (Cr-Au, 3×3) coated with electrospun nanofibrous structures. These were comprised of doped polyemeraldine base blended with 3 different polymers: polyethylene oxide, polyvinilpyrrolidone and polystyrene, which acted as carriers for the conducting polymer and were the major responsible of the features of each fibrous overlay (electrical parameters, selectivity and sensitivity ranges). The two sensing strategies here adopted and compared consisted in the use of 2 different textural coatings: a single- and a double-overlay, where the double-overlay resulting from overdeposition of 2 different polymer blends. Such e-nose included a plurality of nanofibres whose electrical parameters were at the same time depending on each polymer exposure to analytes (NO(2), NH(3)) and on the spatial distribution of the interlacing fibres. The morphology of the coating arrangements of this novel e-nose was investigated by scanning electron microscopy (SEM) and its sensor responses were processed by multicomponent data analyses (PCA and PLS) reporting encouraging results for detection and recognition of analytes at ppb levels.
本研究的目的是将生物启发的纳米纤维人工上皮与电子鼻（e-nose）原理相结合。所建立的传感装置是一个电子鼻，由 9 个微化学电阻器（Cr-Au，3×3）阵列组成，这些电阻器涂有静电纺纳米纤维结构。这些结构由掺杂的聚emeraldine 基与 3 种不同的聚合物混合而成：聚氧化乙烯、聚维酮和聚苯乙烯，它们作为导电聚合物的载体，是每种纤维覆盖物（电参数、选择性和灵敏度范围）特征的主要负责者。这里采用并比较了两种传感策略，包括使用两种不同的纹理涂层：单层和双层，其中双层是通过两种不同聚合物混合物的过度沉积形成的。这种 e-nose 包括多个纳米纤维，其电参数同时取决于每种聚合物对分析物（NO(2)、NH(3)）的暴露以及交织纤维的空间分布。通过扫描电子显微镜（SEM）研究了这种新型 e-nose 的涂层排列的形态，其传感器响应通过多组分数据分析（PCA 和 PLS）进行处理，为 ppb 水平的分析物检测和识别提供了令人鼓舞的结果。
