Griez E, de Loof C, Pols H, Zandbergen J, Lousberg H
Academic Anxiety Center, Vijverdal Mental Hospital, State University of Maastricht, The Netherlands.
Psychiatry Res. 1990 Feb;31(2):193-9. doi: 10.1016/0165-1781(90)90121-k.
One inhalation of 35% CO2 in oxygen was administered to 36 patients with anxiety disorders and 14 healthy controls. Eighteen patients had a diagnosis of panic disorder (PD) and 18 of obsessive-compulsive disorder (OCD). As a placebo control for CO2, compressed air was administered in a double-blind design. Immediately before and after the inhalation, levels of anxiety and DSM-III-R symptoms of panic were assessed. CO2 elicited high levels of subjective anxiety in the PD group. Patients with OCD were hardly affected by the inhalation, and did not differ from healthy controls. These results suggest that CO2 challenge should be considered as a specific probe for subjects with panic-anxiety. It is speculated that CO2 may trigger some as yet undefined mechanisms, possibly linked to ventilation control, which demarcate panic from other types of pathological anxiety.
对36名焦虑症患者和14名健康对照者进行了一次吸入含35%二氧化碳的氧气的操作。其中18名患者被诊断为惊恐障碍（PD），18名被诊断为强迫症（OCD）。作为二氧化碳的安慰剂对照，采用双盲设计给予压缩空气。在吸入前和吸入后立即评估焦虑水平和惊恐的DSM-III-R症状。二氧化碳在PD组引发了高水平的主观焦虑。OCD患者几乎未受吸入影响，与健康对照者无差异。这些结果表明，二氧化碳激发试验应被视为惊恐焦虑症患者的一种特异性检测方法。据推测，二氧化碳可能触发一些尚未明确的机制，可能与通气控制有关，这些机制将惊恐与其他类型的病理性焦虑区分开来。
