van den Hout M A, van der Molen G M, Griez E, Lousberg H, Nansen A
Am J Psychiatry. 1987 Jun;144(6):788-91. doi: 10.1176/ajp.144.6.788.
The authors compared the subjective reaction of 13 panic patients and eight control subjects to a 35% CO2 challenge, a treatment known to produce physical symptoms comparable to those of natural or lactate-induced panic, and to placebo treatment (inhalation of air). They found that patients had higher placebo scores than control subjects, patients tended to get highly anxious on CO2 and control subjects did not, and CO2-induced subjective anxiety in patients decreased as the number of CO2-induced exposures to interoceptive anxiety symptoms increased. The data support a behavioral account of the effects of anxiogenics.
作者比较了13名惊恐障碍患者和8名对照受试者对35%二氧化碳激发试验、一种已知能产生与自然或乳酸诱发的惊恐相似身体症状的治疗方法以及安慰剂治疗（吸入空气）的主观反应。他们发现，患者的安慰剂评分高于对照受试者，患者在接触二氧化碳时往往会变得高度焦虑，而对照受试者则不会，并且随着因接触二氧化碳而诱发的内感受性焦虑症状次数的增加，患者因二氧化碳诱发的主观焦虑会降低。这些数据支持了对应激原作用的行为学解释。
