血小板输注：对止血、血栓形成、炎症和临床结局的影响。
Platelet transfusions: impact on hemostasis, thrombosis, inflammation and clinical outcomes.
机构信息
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642,USA.
出版信息
Thromb Res. 2011 Apr;127(4):287-91. doi: 10.1016/j.thromres.2010.10.012. Epub 2010 Nov 19.
Abstract
Platelet transfusion is one of the most crucial therapeutic approaches in Medicine. However, severe and fatal adverse reactions may develop. In addition to their important function in hemostasis, platelets' role in inflammation has become more evident. Recently, platelets are also recognized as the main source of circulating soluble CD40 ligand (sCD40L, (CD154)), which plays significant roles in hemostasis, platelet activation, clot stability, interactions with other cells, and upregulation of different mediators. In this review, we will briefly highlight the importance of platelet transfusion, its role in inflammatory and thrombotic transfusion reactions, and visit the most recent findings on sCD40L.
摘要
血小板输注是医学中最重要的治疗方法之一。然而，可能会出现严重和致命的不良反应。除了在止血方面的重要作用外，血小板在炎症中的作用也变得更加明显。最近，血小板也被认为是循环可溶性 CD40 配体 (sCD40L，(CD154)) 的主要来源，它在止血、血小板激活、血栓稳定性、与其他细胞的相互作用以及不同介质的上调中起着重要作用。在这篇综述中，我们将简要强调血小板输注的重要性、它在炎症和血栓性输血反应中的作用，并探讨 sCD40L 的最新发现。
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