Ren Yijie, Zhou Hongxia, Lu Jin, Huang Sicheng, Zhu Haomiao, Li Li
National and Local Joint Engineering Research Center of Biomedical Functional Materials, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210023, China.
School of Chemistry and Materials Science, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing 210023, China.
Membranes (Basel). 2020 Dec 17;10(12):431. doi: 10.3390/membranes10120431.
Diseases and complications related to catheter materials are severe problems in biomedical material applications, increasing the infection risk and medical expenses. Therefore, there is an enormous demand for catheter materials with antibacterial and antifouling properties. Considering this, in this work, we developed an approach of constructing antibacterial surfaces on polyurethane (PU) via surface-initiated atom transfer radical polymerization (SI-ATRP). A variety of cationic polymers were grafted on PU. The biocompatibility and antifouling properties of all resulting materials were evaluated and compared. We also used a theoretical algorithm to investigate the anticoagulant mechanism of our PU-based grafts. The hemocompatibility and anti-biofouling performance improved at a 86-112 μg/cm grafting density. The theoretical simulation demonstrated that the in vivo anti-fouling performance and optimal biocompatibility of our PU-based materials could be achieved at a 20% grafting degree. We also discuss the mechanism responsible for the hemocompatibility of the cationic brushes fabricated in this work. The results reported in this paper provide insights and novel ideas on material design for applications related to medical catheters.
与导管材料相关的疾病和并发症是生物医学材料应用中的严重问题，会增加感染风险和医疗费用。因此，对具有抗菌和防污性能的导管材料有巨大需求。考虑到这一点，在这项工作中，我们开发了一种通过表面引发原子转移自由基聚合（SI-ATRP）在聚氨酯（PU）上构建抗菌表面的方法。多种阳离子聚合物接枝到PU上。对所有所得材料的生物相容性和防污性能进行了评估和比较。我们还使用理论算法研究了基于PU的接枝物的抗凝机制。在接枝密度为86-112μg/cm时，血液相容性和抗生物污损性能得到改善。理论模拟表明，在接枝度为20%时，可以实现基于PU的材料的体内防污性能和最佳生物相容性。我们还讨论了这项工作中制备的阳离子刷血液相容性的作用机制。本文报道的结果为与医用导管相关的应用的材料设计提供了见解和新思路。
