Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
J Neuroimmunol. 2011 Jan;230(1-2):164-8. doi: 10.1016/j.jneuroim.2010.10.028. Epub 2010 Nov 19.
Multiple sclerosis (MS) is a central nervous system inflammatory disorder with evidence of peripheral immune dysregulation. Abnormalities of the immune suppressive cytokine TGF-β have been reported, but not fully defined, in MS. Through a pathway-focused expression profiling of the peripheral blood, we found abnormalities of TGF-βRII, SMAD4 and SMAD7 expression in subjects with MS, and reduction in the levels of TGF-β regulated genes, indicating an overall reduction in TGF-β signaling in MS. The response to exogenous TGF-β was intact, however, indicating an extrinsic defect of TGF-β signaling in MS. These results indicate that TGF-β control is diminished in MS.
多发性硬化症（MS）是一种中枢神经系统炎症性疾病，有外周免疫失调的证据。已经报道了 MS 中免疫抑制细胞因子 TGF-β 的异常，但尚未完全确定。通过对外周血进行通路聚焦的表达谱分析，我们发现 MS 患者存在 TGF-βRII、SMAD4 和 SMAD7 表达异常，以及 TGF-β 调节基因水平降低，表明 TGF-β 信号在 MS 中总体减少。然而，外源性 TGF-β 的反应是完整的，表明 MS 中 TGF-β 信号的外在缺陷。这些结果表明 TGF-β 控制在 MS 中减弱。
