Tankanow R M, Ross M B, Ertel I J, Dickinson D G, McCormick L S, Garfinkel J F
Department of Pharmacy Services, University of Michigan Hospitals, Ann Arbor 48109.
DICP. 1990 Apr;24(4):382-4. doi: 10.1177/106002809002400408.
The disruption of the natural flora of the gastrointestinal tract (especially Lactobacillus acidophilus) may occur during antibiotic therapy. This may lead to diarrhea, dehydration, and electrolyte imbalances. It has been suggested that replacement of the lactobacilli with a commercially available product may prevent the diarrhea. The efficacy and safety of prophylactically administered Lactinex (culture of L. acidophilus and L. bulgaricus) was compared with placebo for the prevention of amoxicillin-induced diarrhea in pediatric patients. Lactinex or placebo was administered four times a day for ten days to coincide with the antibiotic therapy. The Lactobacillus preparation did not appear to consistently prevent diarrhea in this patient population. Patients' age, diet, and parental definition of diarrhea were factors that may have influenced the results.
在抗生素治疗期间，胃肠道自然菌群（尤其是嗜酸乳杆菌）可能会受到破坏。这可能导致腹泻、脱水和电解质失衡。有人提出，用市售产品替代乳酸杆菌可能预防腹泻。将预防性给予拉克替醇（嗜酸乳杆菌和保加利亚乳杆菌培养物）与安慰剂进行比较，以预防儿科患者阿莫西林诱导的腹泻。拉克替醇或安慰剂每天服用4次，持续10天，与抗生素治疗同步。在该患者群体中，乳酸杆菌制剂似乎并不能始终预防腹泻。患者的年龄、饮食以及家长对腹泻的定义可能是影响结果的因素。
