Laboratório de Bioquímica Adaptativa, Departamento de Química, Universidade Federal de Santa Maria, 97105.900 Santa Maria, RS, Brazil.
Ecotoxicol Environ Saf. 2011 Mar;74(3):328-35. doi: 10.1016/j.ecoenv.2009.05.013. Epub 2010 Nov 20.
Cyprinus carpio was exposed to imazethapyr and imazapic at laboratory and at field conditions. The laboratory experiment was carried out for 7 days and at rice field for 7, 30 and 90 days. Oxidative stress parameters and antioxidant profile were studied as well as metabolic parameters. After 7 days, brain AChE activity increases in laboratory and field, but in muscle, reduction was observed only in laboratory. At the same period, brain and muscle TBARS and liver CAT increase in the laboratory. Metabolic parameters showed changes in both conditions and exposure periods. After 30 days in rice field, brain AChE activity decreases and in muscle it was enhanced. After 90 days in field, only muscle AChE activity was reduced. The disorders in oxidative stress parameters and metabolism remained, indicating mainly a protein catabolism. This study pointed out short- and long-term effects of rice herbicides at environmentally relevant concentrations on toxicological parameters in tissues of C. carpio.
鲤鱼在实验室和田间条件下分别暴露于咪草烟和异丙甲草胺中。实验室实验进行了 7 天，田间实验则进行了 7、30 和 90 天。研究了氧化应激参数和抗氧化谱以及代谢参数。7 天后，大脑 AChE 活性在实验室和田间均增加，但在肌肉中，仅在实验室观察到减少。在同一时期，大脑和肌肉中的 TBARS 和肝脏中的 CAT 在实验室中增加。两种条件和暴露期均发生了代谢参数的变化。在稻田中 30 天后，大脑 AChE 活性降低，而肌肉中的活性增强。在田间 90 天后，仅肌肉 AChE 活性降低。氧化应激参数和代谢的紊乱仍然存在，主要表明存在蛋白质分解代谢。这项研究指出了在环境相关浓度下，稻田除草剂对鲤鱼组织的毒理学参数的短期和长期影响。
