LSU Health Sciences Center, Department of Genetics, CSRB 657, 533 Bolivar St., New Orleans, LA 70112, USA.
Cytokine Growth Factor Rev. 2010 Dec;21(6):443-8. doi: 10.1016/j.cytogfr.2010.11.002. Epub 2010 Nov 20.
The T helper type 17 (Th17) lineage of CD4+ T-cells produce several effector molecules including IL-17A, IL-17F, IL-21, and IL-22. In addition to CD4+, αβ T-cells, these cytokines can be produced by natural killer and γδ T-cells. These effector cytokines can be produced rapidly upon infection at mucosal sites and evidence to date strongly implicates that this arm of the immune system plays a critical role in mucosal immunity to many extracellular pathogens. Moreover these cytokines can also coordinate adaptive immunity to some intracellular pathogens. In this review, we will highlight recent progress in our understanding of these cytokines, and mechanisms of their effector function in the mucosa.
辅助性 T 细胞 17（Th17）亚群的 CD4+T 细胞可产生多种效应分子，包括白细胞介素 17A（IL-17A）、白细胞介素 17F（IL-17F）、白细胞介素 21（IL-21）和白细胞介素 22（IL-22）。除 CD4+αβ T 细胞外，这些细胞因子还可由自然杀伤（NK）T 细胞和 γδ T 细胞产生。这些效应细胞因子可在黏膜部位感染时迅速产生，目前的证据强烈表明，免疫系统的这一支在针对许多细胞外病原体的黏膜免疫中发挥着关键作用。此外，这些细胞因子还可以协调对某些细胞内病原体的适应性免疫。在这篇综述中，我们将重点介绍对这些细胞因子的理解以及它们在黏膜中的效应功能的机制方面的最新进展。
