Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Curr Opin Chem Biol. 2011 Feb;15(1):11-21. doi: 10.1016/j.cbpa.2010.10.027. Epub 2010 Nov 20.
In recent years, the number of known peptide natural products that are synthesized via the ribosomal pathway has rapidly grown. Taking advantage of sequence homology among genes encoding precursor peptides or biosynthetic proteins, in silico mining of genomes combined with molecular biology approaches has guided the discovery of a large number of new ribosomal natural products, including lantipeptides, cyanobactins, linear thiazole/oxazole-containing peptides, microviridins, lasso peptides, amatoxins, cyclotides, and conopeptides. In this review, we describe the strategies used for the identification of these ribosomally synthesized and posttranslationally modified peptides (RiPPs) and the structures of newly identified compounds. The increasing number of chemical entities and their remarkable structural and functional diversity may lead to novel pharmaceutical applications.
近年来，通过核糖体途径合成的已知肽类天然产物的数量迅速增加。利用编码前体肽或生物合成蛋白的基因之间的序列同源性，通过计算机对基因组进行挖掘，并结合分子生物学方法，指导了大量新的核糖体天然产物的发现，包括lantipeptides、cyanobactins、含线性噻唑/噁唑的肽、microviridins、lasso 肽、鹅膏蕈碱、环肽和 conopeptides。在这篇综述中，我们描述了用于鉴定这些核糖体合成和翻译后修饰肽（RiPPs）的策略，以及新鉴定化合物的结构。越来越多的化学实体及其显著的结构和功能多样性可能会导致新的药物应用。
