Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin Carbone Cancer Center, Madison, WI 53705, USA.
Endocrinol Metab Clin North Am. 2010 Dec;39(4):801-10. doi: 10.1016/j.ecl.2010.08.002.
Although neuroendocrine tumors are rare, the more common types such as gastrointestinal and pancreatic carcinoids, medullary thyroid cancers, and small cell lung cancers have been studied in detail during the last few years. Data published thus far indicate that multiple signaling pathways are involved in these cancers. Recent focus has been on developing novel therapeutics by targeting specific signaling pathways. This article details several of the signaling mechanisms that have been discovered to play a role in the development and progression of neuroendocrine tumors. The therapeutic options developed to address the various pathways, including their specific mechanisms of actions, are also discussed.
虽然神经内分泌肿瘤比较少见，但是近年来，人们对较为常见的类型（如胃肠道和胰腺神经内分泌癌、甲状腺髓样癌和小细胞肺癌）进行了详细的研究。到目前为止发表的数据表明，多种信号通路参与了这些癌症的发生发展。目前的研究重点是通过针对特定信号通路来开发新的治疗方法。本文详细介绍了几种已发现的在神经内分泌肿瘤的发生和进展中起作用的信号机制。本文还讨论了为解决各种信号通路而开发的治疗选择，包括它们的具体作用机制。
