Ganesan K, Stacey A, Meffin H, Lichter S, Greferath U, Fletcher E L, Prawer S
School of Physics, The University of Melbourne, Parkville, VIC 3010, Australia.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:6757-60. doi: 10.1109/IEMBS.2010.5626003.
This paper presents progress in the characterization and application of diamond penetrating electrode arrays for Epi-Retinal Prostheses. Electrical stimulation of degenerate retina has already been shown to restore partial vision for some blind patients, albeit at low spatial resolution. Higher resolution may be achievable by building arrays with electrodes that have greater areal density and closer proximity to target neurons. However, high standards of biocompatibility and hermeticity must be maintained, limiting the range of available materials of manufacture. Here, the design and histology of high density electrode arrays (approximately 100 electrodes/mm(2)) made from polycrystalline diamond and implanted into rat retinae are discussed. Results from initial steps in this process are reported.
本文介绍了用于视网膜假体的金刚石穿透电极阵列的特性及应用进展。对退化视网膜进行电刺激已被证明能为一些失明患者恢复部分视力,尽管空间分辨率较低。通过构建具有更大面密度且更靠近目标神经元的电极阵列,或许可以实现更高的分辨率。然而,必须维持高标准的生物相容性和气密性,这限制了可用制造材料的范围。在此,我们讨论了由多晶金刚石制成并植入大鼠视网膜的高密度电极阵列(约100个电极/平方毫米)的设计和组织学情况,并报告了这一过程初始步骤的结果。