Damle Samir, Liu Yu-Hsin, Arya Shaurya, Oesch Nicholas W, Lo Yu-Hwa
Department of Bioengineering, University of California San Diego, 9500 Gilman Drive La Jolla, CA 92093, USA.
Nanovision Biosciences, Inc., 3366 N. Torrey Pines Court, Suite 220, La Jolla, CA 92037, USA.
Biomed Opt Express. 2019 Dec 4;11(1):55-67. doi: 10.1364/BOE.11.000055. eCollection 2020 Jan 1.
Optoelectronic retinal prostheses transduce light into electrical current for neural stimulation. We introduce a novel optoelectronic pixel architecture consisting of a vertically integrated photo junction-field-effect transistor (Photo-JFET) and neural stimulating electrode. Experimental measurements demonstrate that optically addressed Photo-JFET pixels utilize phototransistive gain to produce a broad range of neural stimulation current and can effectively stimulate retinal neurons in vitro. The compact nature of the Photo-JFET pixel can enable high resolution retinal prostheses with the smallest reported optoelectronic pixel size to help restore high visual acuity in patients with degenerative retinal diseases.
光电视网膜假体将光转换为电流以进行神经刺激。我们介绍了一种新型的光电像素架构，它由垂直集成的光结场效应晶体管（光电结型场效应晶体管）和神经刺激电极组成。实验测量表明，光寻址的光电结型场效应晶体管像素利用光晶体管增益产生广泛的神经刺激电流，并且能够在体外有效刺激视网膜神经元。光电结型场效应晶体管像素的紧凑特性能够实现具有已报道最小光电像素尺寸的高分辨率视网膜假体，以帮助恢复患有退行性视网膜疾病患者的高视力。
