Patrick Erin, Sankar Viswanath, Rowe William, Sanchez Justin C, Nishida Toshikazu
Department of Electrical and Computer Engineering, University of Florida, Gainesville, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:1816-9. doi: 10.1109/IEMBS.2010.5626419.
One of the important challenges in designing Brain-Machine Interfaces (BMI) is to build implantable systems that have the ability to reliably process the activity of large ensembles of cortical neurons. In this paper, we report the design, fabrication, and testing of a polyimide-based microelectrode array integrated with a low-power amplifier as part of the Florida Wireless Integrated Recording Electrode (FWIRE) project at the University of Florida developing a fully implantable neural recording system for BMI applications. The electrode array was fabricated using planar micromachining MEMS processes and hybrid packaged with the amplifier die using a flip-chip bonding technique. The system was tested both on bench and in-vivo. Acute and chronic neural recordings were obtained from a rodent for a period of 42 days. The electrode-amplifier performance was analyzed over the chronic recording period with the observation of a noise floor of 4.5 microVrms, and an average signal-to-noise ratio of 3.8.
设计脑机接口（BMI）的重要挑战之一是构建能够可靠处理大量皮层神经元活动的可植入系统。在本文中，作为佛罗里达大学佛罗里达无线集成记录电极（FWIRE）项目的一部分，我们报告了一种集成了低功耗放大器的基于聚酰亚胺的微电极阵列的设计、制造和测试情况，该项目旨在开发一种用于BMI应用的完全可植入神经记录系统。电极阵列采用平面微加工微机电系统工艺制造，并使用倒装芯片键合技术与放大器芯片进行混合封装。该系统在实验台和体内均进行了测试。从一只啮齿动物身上获得了长达42天的急性和慢性神经记录。在慢性记录期间对电极 - 放大器性能进行了分析，观察到本底噪声为4.5微伏均方根值，平均信噪比为3.8。
