Borton David A, Song Yoon-Kyu, Patterson William R, Bull Christopher W, Park Sunmee, Laiwalla Farah, Donoghue John P, Nurmikko Arto V
Division of Engineering, Brown University, Providence, RI 02912, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:5531-4. doi: 10.1109/IEMBS.2009.5333189.
A multitude of neuroengineering challenges exist today in creating practical, chronic multichannel neural recording systems for primate research and human clinical application. Specifically, a) the persistent wired connections limit patient mobility from the recording system, b) the transfer of high bandwidth signals to external (even distant) electronics normally forces premature data reduction, and c) the chronic susceptibility to infection due to the percutaneous nature of the implants all severely hinder the success of neural prosthetic systems. Here we detail one approach to overcome these limitations: an entirely implantable, wirelessly communicating, integrated neural recording microsystem, dubbed the Brain Implantable Chip (BIC).
如今，在为灵长类动物研究和人类临床应用创建实用的慢性多通道神经记录系统方面，存在众多神经工程学挑战。具体而言，a) 持续的有线连接限制了患者与记录系统之间的移动性，b) 将高带宽信号传输到外部（甚至是远距离的）电子设备通常会迫使过早地进行数据缩减，并且c) 由于植入物的经皮性质而导致的长期感染易感性，所有这些都严重阻碍了神经假体系统的成功。在此，我们详细介绍一种克服这些限制的方法：一种完全可植入、无线通信的集成神经记录微系统，称为脑植入芯片（BIC）。
