Santaniello S, Gale J T, Montgomery E B, Sarma S V
Institute of Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:2081-4. doi: 10.1109/IEMBS.2010.5626285.
Deep Brain Stimulation (DBS) is an effective surgical therapy for the treatment of movement disorders in Parkinson's disease (PD) and other neurological pathologies. DBS is known to modulate the spiking activity of the neurons within the basal ganglia, but how such modulation impacts the primary sensorimotor cortex is still uncertain. In this study a monkey was stimulated with DBS at several frequencies in the subthalamic nucleus (STN) before and after treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to develop PD symptoms, while single unit recordings are simultaneously obtained from the sensorimotor cortex. We exploit such data to develop point-process input-output models of the cortical neurons. Our models describe the effects of stimulation in normal and MPTP conditions and investigate the influence of the stimulation frequency on the neuronal activity. Our models show increased synchronization of the cortical neurons in MPTP vs. normal conditions before stimulation, suggest that STN DBS impacts the cortical activity by antidromically eliciting spikes at the stimulation frequency, and support the hypothesis that high frequency DBS partially masks the effects of thalamo-cortical input.
深部脑刺激（DBS）是治疗帕金森病（PD）和其他神经病理学运动障碍的一种有效手术疗法。已知DBS可调节基底神经节内神经元的放电活动，但这种调节如何影响初级感觉运动皮层仍不确定。在本研究中，在用1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱发PD症状前后，以几种频率对一只猴子的丘脑底核（STN）进行DBS刺激，同时从感觉运动皮层进行单神经元记录。我们利用这些数据建立皮层神经元的点过程输入-输出模型。我们的模型描述了正常和MPTP条件下刺激的效果，并研究了刺激频率对神经元活动的影响。我们的模型显示，在刺激前，MPTP条件下皮层神经元的同步性高于正常条件，这表明STN DBS通过以刺激频率逆向诱发动作电位来影响皮层活动，并支持高频DBS部分掩盖丘脑-皮层输入效应这一假说。
